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帕罗西汀联合小剂量米氮平治疗哺乳期妇女的短期安全性。

Short-Term Safety of Paroxetine Plus Low-Dose Mirtazapine During Lactation.

机构信息

Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University , Konya, Turkey .

出版信息

Breastfeed Med. 2019 Mar;14(2):131-132. doi: 10.1089/bfm.2018.0197. Epub 2018 Nov 29.

DOI:10.1089/bfm.2018.0197
PMID:30489153
Abstract

Selective serotonin reuptake inhibitors (SSRIs), especially sertraline and paroxetine, are first-line antidepressants in the treatment of postpartum depression in breastfeeding women as these drugs are well tolerated by most breastfed infants. Although some women with these diagnoses require additional antidepressants to SSRIs, the safety of combined usage of SSRIs and mirtazapine is currently unknown. This report includes short-term safety data of breastfed infants exposed to paroxetine plus low-dose mirtazapine.

摘要

选择性 5-羟色胺再摄取抑制剂(SSRIs),尤其是舍曲林和帕罗西汀,是母乳喂养妇女产后抑郁症治疗的一线药物,因为这些药物大多数情况下能被母乳喂养的婴儿良好耐受。尽管一些患有这些疾病的妇女需要在 SSRIs 基础上增加使用其他抗抑郁药,但目前尚不清楚 SSRIs 和米氮平联合使用的安全性。本报告包括了暴露于帕罗西汀加低剂量米氮平的母乳喂养婴儿的短期安全性数据。

相似文献

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Short-Term Safety of Paroxetine Plus Low-Dose Mirtazapine During Lactation.帕罗西汀联合小剂量米氮平治疗哺乳期妇女的短期安全性。
Breastfeed Med. 2019 Mar;14(2):131-132. doi: 10.1089/bfm.2018.0197. Epub 2018 Nov 29.
2
Better Tolerance of Citalopram in a Breastfed Infant Who Could Not Tolerate Sertraline and Paroxetine.一名无法耐受舍曲林和帕罗西汀的母乳喂养婴儿对西酞普兰的耐受性更好。
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Short-Term Safety of Paroxetine and Sertraline in Breastfed Infants: A Retrospective Cohort Study from a University Hospital.帕罗西汀和舍曲林在母乳喂养婴儿中的短期安全性:一项来自大学医院的回顾性队列研究。
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[The transfer of selective serotonin reuptake inhibitors to human milk].[选择性5-羟色胺再摄取抑制剂向母乳中的转移]
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Breastfeeding during maternal antidepressant treatment with serotonin reuptake inhibitors: infant exposure, clinical symptoms, and cytochrome p450 genotypes.母亲在使用5-羟色胺再摄取抑制剂进行抗抑郁治疗期间进行母乳喂养:婴儿暴露情况、临床症状及细胞色素P450基因型
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引用本文的文献

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Mirtazapine in pregnancy and lactation: A systematic review of adverse outcomes.米氮平在妊娠和哺乳期的应用:不良结局的系统评价
Acta Psychiatr Scand. 2025 Jan;151(1):6-32. doi: 10.1111/acps.13749. Epub 2024 Aug 31.
2
Consensus Panel Recommendations for the Pharmacological Management of Breastfeeding Women with Postpartum Depression.共识专家组关于产后抑郁症哺乳期妇女药物治疗的推荐意见。
Int J Environ Res Public Health. 2024 Apr 26;21(5):551. doi: 10.3390/ijerph21050551.
3
Sex- and age- dependent effect of pre-gestational chronic stress and mirtazapine treatment on neurobehavioral development of Wistar rat offspring.
妊娠前慢性应激和米氮平治疗对Wistar大鼠后代神经行为发育的性别和年龄依赖性影响。
PLoS One. 2022 Feb 3;17(2):e0255546. doi: 10.1371/journal.pone.0255546. eCollection 2022.