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盆腔痛与顶端脱垂手术:基于人群的回顾性队列研究。

Pelvic Pain and Apical Prolapse Surgery: A Population-Based Retrospective Cohort Study.

机构信息

From the Department of Gynecology & Obstetrics, Johns Hopkins University, Baltimore, MD.

Department of Obstetrics and Gynecology, Yale University, New Haven, CT.

出版信息

Female Pelvic Med Reconstr Surg. 2020 Nov;26(11):704-711. doi: 10.1097/SPV.0000000000000674.

Abstract

OBJECTIVES

The aims of this study were to evaluate the association of preoperative pelvic pain with operative characteristics and the association of patient and operative characteristics with postoperative pain.

METHODS

This is a retrospective cohort study utilizing Clinformatics DataMart, a large national commercial insurance database. We collected data for patients older than 18 years who underwent apical prolapse surgery between January 2005 and December 2014. We stratified data by preoperative (prior) pain and analyzed for associations of prior and postoperative pain. Logistic regression analysis was performed using SAS software.

RESULTS

A total of 14,440 patients met inclusion criteria and were analyzed. Patients with prior pain were more likely to have an abdominal (open or laparoscopic) approach, a concomitant hysterectomy, but less likely to have additional repairs or a mesh insertion (P < 0.001). Postoperative pain was less with a concomitant hysterectomy, whether they had prior pain (odds ratio [OR], 0.56; 95% confidence interval [CI], 0.41-0.77) or not (OR, 0.68; 95% CI, 0.56-0.82). Additional vaginal repairs were associated with more postoperative pain for those without prior pain (OR, 1.63; 95% CI, 1.3-2.04). Age older than 45 years was associated with less pain. Length of hospital stay of more than 2 days was associated with more pain.

CONCLUSIONS

Patients with prior pain were more likely to undergo an abdominal approach and have a concomitant hysterectomy. Postoperative pain was less with a concomitant hysterectomy, but more with additional vaginal repairs. There is a need to include pain as an outcome in future studies, particularly clinical trials.

摘要

目的

本研究旨在评估术前盆腔痛与手术特点的关系,以及患者和手术特点与术后疼痛的关系。

方法

这是一项回顾性队列研究,利用 Clinformatics DataMart,一个大型的全国商业保险数据库。我们收集了 2005 年 1 月至 2014 年 12 月期间接受 apical prolapse 手术的年龄大于 18 岁的患者数据。我们按术前(既往)疼痛分层数据,并分析了既往和术后疼痛的相关性。使用 SAS 软件进行逻辑回归分析。

结果

共有 14440 名患者符合纳入标准并进行了分析。有既往疼痛史的患者更有可能采用腹部(开放或腹腔镜)入路和同时行子宫切除术,但不太可能进行额外的修补或网片插入(P<0.001)。同时行子宫切除术与术后疼痛减轻相关,无论患者是否有既往疼痛史(比值比 [OR],0.56;95%置信区间 [CI],0.41-0.77)或无既往疼痛史(OR,0.68;95%CI,0.56-0.82)。对于无既往疼痛史的患者,额外的阴道修补术与更多的术后疼痛相关(OR,1.63;95%CI,1.3-2.04)。年龄大于 45 岁与疼痛减轻相关。住院时间超过 2 天与更多的疼痛相关。

结论

有既往疼痛史的患者更有可能采用腹部入路和同时行子宫切除术。同时行子宫切除术与术后疼痛减轻相关,但与额外的阴道修补术相关的疼痛更多。未来的研究,特别是临床试验,需要将疼痛作为一个结局纳入。

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