膳食纤维与胰腺癌风险

Dietary Fiber and the Risk of Pancreatic Cancer.

作者信息

Koulouris Andreas I, Luben Robert, Banim Paul, Hart Andrew R

机构信息

Institute of Public Health, University of Cambridge, Cambridge.

Department of Gastroenterology, James Paget University Hospital, Great Yarmouth, United Kingdom.

出版信息

Pancreas. 2019 Jan;48(1):121-125. doi: 10.1097/MPA.0000000000001191.

DOI:10.1097/MPA.0000000000001191

PMID:30489447

Abstract

OBJECTIVES

High dietary fiber may protect against pancreatic ductal adenocarcinoma (PDAC). We investigated associations between fiber intake and the risk of PDAC using for the first time 7-day food diaries.

METHODS

Participants in the European Prospective Investigation Into Cancer-Norfolk completed the 7-day food diaries at recruitment. The cohort was followed up for 17 years to identify those who developed PDAC. Participants were divided into quintiles of fiber intake, and hazard ratios (HR) were estimated with their 95% confidence intervals (CIs). Fiber was tested for effect modification of high red and processed meat intake and smoking and the risk of PDAC.

RESULTS

No significant associations for any quintiles of intake (HR Q5 vs Q1, 1.08; 95% CI, 0.56-2.08) were detected with no trend across quintiles. A high-fiber diet modified positive associations between red and processed meats with the development of PDAC (HR trends, 0.89 [95% CI, 0.47-1.69] and 1.02 [95% CI, 0.55-1.88], respectively) but not those with lower fiber intake. Fiber intake did not modify the risk of PDAC in past and current smokers.

CONCLUSION

The findings do not suggest that fiber protects against PDAC, although it may decrease potential deleterious effects of meats.

摘要

目的

高膳食纤维可能预防胰腺导管腺癌（PDAC）。我们首次使用7天食物日记来研究膳食纤维摄入量与PDAC风险之间的关联。

方法

欧洲癌症与营养前瞻性调查-诺福克队列研究的参与者在招募时完成了7天食物日记。对该队列进行了17年的随访，以确定那些患PDAC的人。参与者被分为膳食纤维摄入量的五个五分位数组，并估计风险比（HR）及其95%置信区间（CI）。对膳食纤维在高红肉和加工肉摄入量、吸烟以及PDAC风险方面的效应修正作用进行了检验。

结果

未检测到任何摄入量五分位数组有显著关联（HR Q5与Q1相比，1.08；95% CI，0.56 - 2.08），且五分位数组间无趋势。高膳食纤维饮食改变了红肉和加工肉与PDAC发生之间的正相关关系（HR趋势分别为0.89 [95% CI，0.47 - 1.69]和1.02 [95% CI，0.55 - 1.88]），但低膳食纤维摄入量组则未改变。膳食纤维摄入量对既往和当前吸烟者的PDAC风险没有修正作用。