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[妊娠期梅毒疑似病例因莱姆病感染中的交叉反应所致]

[Suspected syphilis during pregnancy due to cross reactions in Borrelia infection].

作者信息

Enders G, Biber M, Baier R, Hlobil H, Wellensiek H J

机构信息

Institut für medizinische Virologie und Infektionsepidemiologie sowie Medizinisches Landesuntersuchungsamt, Stuttgart.

出版信息

Dtsch Med Wochenschr. 1988 Sep 30;113(39):1511-4. doi: 10.1055/s-2008-1067843.

Abstract

A weakly positive titre (1:20) in the Treponema pallidum haemagglutination test and a highly positive titre (1:1280) in the fluorescence Treponema antibody absorption test, but negative result for IgM antibodies, were found in the serum of a 23-year-old pregnant woman. The cardiolipin microflocculation test was at first borderline positive, but negative on repeat. In the absence of a history of syphilis tests for Borrelia antibodies were performed. Those for antibodies against B. burgdorferi were highly positive in the ELISA test (550 units), in the indirect Borrelia immunofluorescence test 1:1280 for IgG antibodies and 1:160 for IgM antibodies. In the Borrelia-specific indirect haemagglutination test, which measures both IgG and IgM antibodies, the titres were 1:640 to 1:1280. These results confirmed the presence of an infection with B. burgdorferi and not with Treponema pallidum.

摘要

在一名23岁孕妇的血清中,梅毒螺旋体血细胞凝集试验结果呈弱阳性(1:20),荧光螺旋体抗体吸收试验结果呈强阳性(1:1280),但IgM抗体检测结果为阴性。心磷脂微量絮凝试验最初结果为临界阳性,但复查为阴性。由于该孕妇无梅毒病史,因此进行了伯氏疏螺旋体抗体检测。在ELISA试验中,抗伯氏疏螺旋体抗体检测结果呈强阳性(550单位),间接伯氏疏螺旋体免疫荧光试验中,IgG抗体效价为1:1280,IgM抗体效价为1:160。在检测IgG和IgM抗体的伯氏疏螺旋体特异性间接血细胞凝集试验中,效价为1:640至1:1280。这些结果证实该孕妇感染的是伯氏疏螺旋体,而非梅毒螺旋体。

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