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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Haga H J, Andersen K J, Rygh T, Iversen B M, Matre R

Medical Department A, University of Bergen, Haukeland Sykehus, Norway.

Int J Biochem. 1988;20(8):793-800. doi: 10.1016/0020-711x(88)90066-3.

Experimental proteinuria (262.9 mg protein/24 hr urine) was induced in rats by repeated intraperitoneal injections of BSA. 2. Hypertrophy of the kidney cortex was significant 8 days after the start of the BSA injections, and the activities of lysosomal enzymes in kidney cortex and urine were significantly higher in proteinuric compared to nonproteinuric rats. 3. Lysosome populations in the kidney cortex were examined by rate sedimentation of the homogenate and by rate zonal and isopycnic centrifugation of the lysosome-rich ML fraction. 4. The activity of lysosomal enzymes in the kidney cortex increased slightly, essentially in the large, fragile lysosomes mainly recovered from the proximal tubule. 5. Proteinuria induced a shift/reduction in the density of small lysosomes from 1.235 and 1.20 g/ml to 1.225 and 1.185 g/ml, respectively. 6. Proteinuria induced a new population of small lysosomes (density 1.185 g/ml) enriched in cathepsin D.

通过反复腹腔注射牛血清白蛋白（BSA）在大鼠中诱导出实验性蛋白尿（24小时尿蛋白262.9毫克）。2. 在开始注射BSA 8天后，肾皮质肥大明显，与无蛋白尿的大鼠相比，蛋白尿大鼠肾皮质和尿液中的溶酶体酶活性显著更高。3. 通过匀浆的速率沉降以及富含溶酶体的ML组分的速率区带离心和等密度离心来检测肾皮质中的溶酶体群体。4. 肾皮质中溶酶体酶的活性略有增加，主要在主要从近端小管回收的大的、易碎的溶酶体中。5. 蛋白尿导致小溶酶体的密度分别从1.235和1.20克/毫升转移/降低至1.225和1.185克/毫升。6. 蛋白尿诱导出一群新的富含组织蛋白酶D的小溶酶体（密度1.185克/毫升）。

Haga H J, Andersen K J, Rygh T, Iversen B M, Matre R

Medical Department A, University of Bergen, Haukeland Sykehus, Norway.

Int J Biochem. 1988;20(8):793-800. doi: 10.1016/0020-711x(88)90066-3.

Experimental proteinuria (262.9 mg protein/24 hr urine) was induced in rats by repeated intraperitoneal injections of BSA. 2. Hypertrophy of the kidney cortex was significant 8 days after the start of the BSA injections, and the activities of lysosomal enzymes in kidney cortex and urine were significantly higher in proteinuric compared to nonproteinuric rats. 3. Lysosome populations in the kidney cortex were examined by rate sedimentation of the homogenate and by rate zonal and isopycnic centrifugation of the lysosome-rich ML fraction. 4. The activity of lysosomal enzymes in the kidney cortex increased slightly, essentially in the large, fragile lysosomes mainly recovered from the proximal tubule. 5. Proteinuria induced a shift/reduction in the density of small lysosomes from 1.235 and 1.20 g/ml to 1.225 and 1.185 g/ml, respectively. 6. Proteinuria induced a new population of small lysosomes (density 1.185 g/ml) enriched in cathepsin D.

通过反复腹腔注射牛血清白蛋白（BSA）在大鼠中诱导出实验性蛋白尿（24小时尿蛋白262.9毫克）。2. 在开始注射BSA 8天后，肾皮质肥大明显，与无蛋白尿的大鼠相比，蛋白尿大鼠肾皮质和尿液中的溶酶体酶活性显著更高。3. 通过匀浆的速率沉降以及富含溶酶体的ML组分的速率区带离心和等密度离心来检测肾皮质中的溶酶体群体。4. 肾皮质中溶酶体酶的活性略有增加，主要在主要从近端小管回收的大的、易碎的溶酶体中。5. 蛋白尿导致小溶酶体的密度分别从1.235和1.20克/毫升转移/降低至1.225和1.185克/毫升。6. 蛋白尿诱导出一群新的富含组织蛋白酶D的小溶酶体（密度1.185克/毫升）。