Seifert H, Jäger K, Bollinger A
Department of Internal Medicine, University Hospital, Zürich, Switzerland.
Int J Microcirc Clin Exp. 1988 Aug;7(3):223-36.
Laser Doppler flux was measured at the forefoot in 12 healthy subjects and in 36 patients with different degrees of ischemia due to peripheral arterial occlusive disease. Two characteristic patterns of flow motion waves were observed: Large waves with a mean amplitude of 0.77 +/- 0.4 arbitrary units and a mean frequency of 3.03 +/- 1.0 c/min (0.051 +/- 0.02 Hz) and small waves with a mean amplitude of 0.21 +/- 0.1 arbitrary units and a mean frequency of 21.7 +/- 4.2 c/min (0.362 +/- 0.07 Hz). The prevalence of large waves tended to decrease with more advanced ischemia, whereas small waves occurred almost exclusively in ischemia and most frequently in severe cases. Large flow motion waves were enhanced during reactive hyperemia after arterial occlusion or appeared after peak flux had been reached. Time to peak flux or to vasomotion were reliable parameters for characterizing skin ischemia. The previously undescribed small flow motion waves might represent a compensatory mechanism involved in pathophysiology of ischemia.
在12名健康受试者以及36名因外周动脉闭塞性疾病导致不同程度缺血的患者中，测量了前足的激光多普勒血流。观察到两种特征性的血流运动波模式：大波平均振幅为0.77±0.4任意单位，平均频率为3.03±1.0次/分钟（0.051±0.02赫兹）；小波平均振幅为0.21±0.1任意单位，平均频率为21.7±4.2次/分钟（0.362±0.07赫兹）。随着缺血程度加重，大波的发生率趋于降低，而小波几乎仅出现在缺血患者中，且在严重病例中最为常见。在动脉闭塞后的反应性充血期间，大波增强，或在达到血流峰值后出现。达到血流峰值或血管运动的时间是表征皮肤缺血的可靠参数。此前未被描述的小血流运动波可能代表了一种参与缺血病理生理过程的代偿机制。
