Lerut J P, Gordon R D, Tzakis A G, Stieber A C, Iwatsuki S, Starzl T E
Helv Chir Acta. 1988 Jul;55(3):367-78.
Hepatic artery thrombosis (HAT) is a dreadful complication of orthotopic liver transplantation (OLT). This complication occurred in 27 grafts (68% = 27/393 grafts) in 25 patients (9% = 25/313 patients). HAT was responsible for a high mortality (64% = 16/25 patients) despite a high retransplantation rate (70% = 19/27 grafts). HAT should be suspected in case of fulminant liver failure, delayed bile leak or unexplained fever of sepsis of unknown etiology occurring after liver transplantation. Pulsed doppler examination and arteriogram are the decisive diagnostic procedures. Patients presenting HAT can only be rescued by early diagnosis and retransplantation. Aneurysms of the hepatic arterial supply must also be treated urgently, either by conventional vascular repair if possible or by retransplantation, because or the high incidence of fatal rupture (3/4 patients = 75%).
肝动脉血栓形成(HAT)是原位肝移植(OLT)的一种可怕并发症。该并发症发生在25例患者(9% = 25/313例患者)的27个移植物中(68% = 27/393个移植物)。尽管再次移植率较高(70% = 19/27个移植物),但HAT导致了高死亡率(64% = 16/25例患者)。肝移植后若出现暴发性肝衰竭、延迟性胆漏或病因不明的不明原因脓毒症发热,应怀疑有HAT。脉冲多普勒检查和动脉造影是决定性的诊断方法。出现HAT的患者只有通过早期诊断和再次移植才能获救。肝动脉供血的动脉瘤也必须紧急治疗,若可能可通过传统血管修复或再次移植,因为其致命破裂的发生率很高(3/4例患者 = 75%)。