Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China.
Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China.
Fitoterapia. 2019 Jan;132:46-52. doi: 10.1016/j.fitote.2018.11.009. Epub 2018 Nov 26.
Seven new naphthoquinone derivatives, named eleutherins A-G (1-7), were isolated from the edible bulbs of Eleutherine americana (Hong-Cong), which belongs to the Iridaceae family. Their structures were elucidated on the basis of spectroscopic analysis including high-resolution-electron spray ionization-mass spectrometry (HR-ESI-MS) and 1D and 2D nuclear magnetic resonance (NMR) techniques. The absolute configurations of compounds 1-4 were determined by experimental and calculated data. Additionally, a hypothetical biosynthetic pathway of 1-7 was postulated. All the isolates were evaluated for their protective effect against the injury of human umbilical vein endothelial cells (HUVECs) in vitro. Eleutherins A and B (1-2) showed a potential protective effect on microvessels.
从属于鸢尾科的葱属植物美洲萱草（Hong-Cong）的可食用鳞茎中分离得到了 7 种新的萘醌衍生物，命名为 Eleutherin A-G（1-7）。基于包括高分辨电子喷雾电离质谱（HR-ESI-MS）和 1D 和 2D 核磁共振（NMR）技术在内的光谱分析确定了它们的结构。通过实验和计算数据确定了化合物 1-4 的绝对构型。此外，还提出了 1-7 的假设生物合成途径。所有分离物均在体外评估了其对人脐静脉内皮细胞（HUVEC）损伤的保护作用。Eleutherin A 和 B（1-2）对微血管显示出潜在的保护作用。
