可溶性破骨细胞相关受体（sOSCAR）与急性冠状动脉综合征的相关性

Correlations of soluble osteoclast-associated receptor (sOSCAR) with acute coronary syndrome.

作者信息

Zhang Qing, Qiao Wei, Zhou Lei, Jin Hui, Zheng Kou-Long, Zhao Dong-Sheng, Lu Hui-He

机构信息

Department of Cardiology, The Second Affiliated Hospital of Nantong University, Nantong 226001, China.

Department of Clinical Laboratory, Nanjing Pukou Hospital, Nanjing 210031, China.

出版信息

Ann Transl Med. 2018 Oct;6(20):408. doi: 10.21037/atm.2018.10.05.

DOI:10.21037/atm.2018.10.05

PMID:30498735

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6230856/

Abstract

BACKGROUND

An osteoclast-associated receptor (OSCAR) is an immunoglobulin receptor expressed in an osteoclast, and takes part in the formation of an osteoclast. While the soluble OSCAR (sOSCAR) component is reported to be involved in the pathogenesis of arteriosclerosis, the aim of this present study is to investigate the relationship between sOSCAR and acute coronary syndrome (ACS).

METHODS

This study enrolled 41 patients with ACS and 33 patients without ACS as a control, from March 2017 to June 2017. The baseline clinical parameters and serum levels of sOSCAR were collected in the participants. The univariate and multivariate logistic regressions were applied to explore the independent association of sOSCAR with ACS. A receiver operating characteristic (ROC) curve was applied to explore the ability of sOSCAR to indicate ACS.

RESULTS

The results showed that the levels of sOSCAR in the patients with ACS was lower than the patients without ACS (P=0.005). The multivariate logistic regression tests demonstrated that a decreased sOSCAR level was independently associated with the presence of ACS (OR: 0.174, 95% CI: 0.047-0.638, P=0.008). ROC analysis showed that the optimal sOSCAR cut-off value for the indication of ACS was <110.87 pg/mL, the corresponding sensitivity was 65.85%, and the specificity was 69.70%.

CONCLUSIONS

The decreased levels of sOSCAR are independently associated with the presence of ACS. sOSCAR could then be considered as a potential biomarker for the prediction of ACS.

摘要

背景

破骨细胞相关受体（OSCAR）是一种在破骨细胞中表达的免疫球蛋白受体，参与破骨细胞的形成。虽然可溶性OSCAR（sOSCAR）成分据报道与动脉粥样硬化的发病机制有关，但本研究的目的是探讨sOSCAR与急性冠状动脉综合征（ACS）之间的关系。

方法

本研究纳入了2017年3月至2017年6月期间41例ACS患者和33例无ACS患者作为对照。收集参与者的基线临床参数和sOSCAR血清水平。应用单因素和多因素逻辑回归分析来探讨sOSCAR与ACS的独立关联。应用受试者工作特征（ROC）曲线来探讨sOSCAR指示ACS的能力。

结果

结果显示，ACS患者的sOSCAR水平低于无ACS患者（P=0.005）。多因素逻辑回归分析表明，sOSCAR水平降低与ACS的存在独立相关（OR：0.174，95%CI：0.047-0.638，P=0.008）。ROC分析显示，指示ACS的最佳sOSCAR截断值<110.87 pg/mL，相应的敏感性为65.85%，特异性为69.70%。