Grusha Y O, Sheptulin V A, Prause J U, Danilov S S
Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021; I.M. Sechenov First Moscow Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991.
Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.
Vestn Oftalmol. 2018;134(5):61-71. doi: 10.17116/oftalma201813405161.
To evaluate the effectiveness of injectable implants made of hyaluronic acid gel (HAG) in ophthalmoplastics.
The study included 57 patients (37 patients with lagophthalmos related to acute or chronic facial nerve palsy, endocrine ophthalmopathy; 20 patients with enophthalmos, anophthalmic syndrome). Depending on filler particle size, the patients received either intrapalpebral or intraorbital HAG injection. The biometric measures of palpebral fissure, the position of the eye/implant, and the condition of the cornea were evaluated during the follow-up period (12 months for eyelid and 18 for orbital injection).
In the course of the follow-up, all patients showed reliable reduction of lagophthalmos; additionally, improvement of the condition of the cornea was observed in patients after intrapalpebral injection; patients after intraorbital injection exhibited reduction in enophthalmos, upper orbital palpebral fold retraction and upper eyelid excursion. No serious complications have occurred after the injection.
As minimally invasive method of treating various pathologies of the orbit and eyelids, HAG fillers showed good clinical effectiveness and safety.
评估透明质酸凝胶(HAG)注射式植入物在眼科整形中的有效性。
该研究纳入57例患者(37例因急性或慢性面神经麻痹、内分泌性眼病导致的兔眼症患者;20例眼球内陷、无眼球综合征患者)。根据填充颗粒大小,患者接受睑内或眶内HAG注射。在随访期间(睑内注射随访12个月,眶内注射随访18个月)评估睑裂的生物测量、眼/植入物位置以及角膜状况。
在随访过程中,所有患者的兔眼症均得到可靠改善;此外,睑内注射患者的角膜状况有所改善;眶内注射患者的眼球内陷、眶上睑皱襞退缩和上睑移动度均有所减轻。注射后未发生严重并发症。
作为治疗眼眶和眼睑各种病变的微创方法,HAG填充剂显示出良好的临床有效性和安全性。