Abramenko Yu V
Tver State Medical University, Tver, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(9. Vyp. 2):42-48. doi: 10.17116/jnevro201811809242.
To evaluate the clinical efficacy, metabolic and membrane protective effects of mexidol for transient ischemic attacks (TIA) in the vertebrobasilar system in elderly patients with chronic cerebral ischemia (CCI).
Fifty-three patients, aged from 60 to 74 years, with the first episode of TIA in the vertebrobasilar system and CCI were examined. Patients of the main group (n=33) received mexidol in the dose of 500 mg for 10 days along with standard therapy, patients of the comparison group (n=20) received only standard therapy. The clinical implications of TIA, laboratory indices of the state of oxidant and antioxidant systems and percentage absorption of lipid-phospholipid complexes in the infrared spectrum of blood serum were studied. The control group consisted of 20 healthy people.
The use of mexidol was associated with more rapid regression of the focal neurological deficit. Mexidol significantly reduced the intensity of lipid peroxidation and had a positive impact on the level of neuronal membrane phospholipids. Metabolic and membrane protective effects of mexidol and it's positive impact on the regression of focal neurological deficit justify its inclusion into complex therapy of TIA in the vertebrobasilar system developed in patients with CCI, especially in elderly patients.
评估美西律对慢性脑缺血（CCI）老年患者椎基底动脉系统短暂性脑缺血发作（TIA）的临床疗效、代谢及膜保护作用。
对53例年龄在60至74岁之间、首次发生椎基底动脉系统TIA且患有CCI的患者进行检查。主要组（n = 33）患者在接受标准治疗的同时，服用剂量为500 mg的美西律，持续10天；对照组（n = 20）患者仅接受标准治疗。研究了TIA的临床意义、氧化和抗氧化系统状态的实验室指标以及血清红外光谱中脂质 - 磷脂复合物的吸收百分比。对照组由20名健康人组成。
使用美西律可使局灶性神经功能缺损更快消退。美西律显著降低脂质过氧化强度，并对神经元膜磷脂水平产生积极影响。美西律的代谢和膜保护作用及其对局灶性神经功能缺损消退的积极影响，证明将其纳入CCI患者（尤其是老年患者）椎基底动脉系统TIA的综合治疗是合理的。
