Center for Clinical Epidemiology, Odense University Hospital, and Research Unit of Clinical Epidemiology, Institute of Clinical Research, University of Southern Denmark, Kløvervænget 30, Entrance 216, ground floor, 5000 Odense C, Denmark.
The Polyvalent Intensive Care Unit, Hospital deSão Francisco Xavier, CHLO, Estrada do Forte do Alto do Duque, 1449-005 Lisbon, Portugal.
Biomark Med. 2018 Nov;12(11):1251-1259. doi: 10.2217/bmm-2018-0043. Epub 2018 Nov 30.
To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.
PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.
RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.
评估 C 反应蛋白（CRP）和血浆白蛋白（PA）水平在菌血症周围的轨迹模式。
基于人群的研究，2418 例社区获得性菌血症患者，在菌血症前 30 天至后 30 天（第 0 天）采集 CRP 和 PA 标本。根据标本是否出现在 -30/-1、0、1/7 或 8/30 天来确定模式。计算模式亚组在 -30/30 天的平均每日 CRP 和 PA 水平。
平均 CRP 在 -5 天上升，在第 1 天达到峰值。在 -30/0 天的平均稳定 PA 急剧下降，此后缓慢增加。各亚组间的轨迹没有差异。我们得出结论，纵向分析结果可以外推到所有社区获得性菌血症患者。
