Kang Hong-Hua, Shu Yong-Qiang, Yang Lin, Zhu Pei-Wen, Li Dan, Li Qing-Hai, Min You-Lan, Ye Lei, Zhou Qiong, Shao Yi
a Department of Ophthalmology , The First Affiliated Hospital of Nanchang University , Nanchang , Jiangxi , China.
b Department of Radiology , The First Affiliated Hospital of Nanchang University , Nanchang , Jiangxi , China.
Int J Neurosci. 2019 Jul;129(7):681-686. doi: 10.1080/00207454.2018.1554657. Epub 2019 Mar 14.
The targets of this study were to access the alternations of spontaneous brain activity in RD patients by amplitude of low-frequency fluctuation (ALFF) method and to explore their relationships with clinical behavioral performance.
A total of 20 patients with RD (6 males and 14 females), and 20 healthy controls (HCs) (6 males and 14 females) were recruited, and were matched in sex and age. All participants finished the functional magnetic resonance imaging (fMRI) scanning. We applied the ALFF method to detect the spontaneous brain activity. Receiver operating characteristic (ROC) curve was applied to distinguish RD Patients from HCs.
RD patients showed decreased ALFF values in the right occipital lobe and right medial frontal gyrus and increased ALFF values in the right frontal superior orbital and left inferior temporal gyrus when compared with HCs. In RD patients, we did not find any relationship between the mean ALFF values and the clinical behavioral performances.
The RD patients exhibited abnormal spontaneous brain activity in vision and vision related brain regions, which might explore potential pathological mechanism of acute vision loss in RD patients.
本研究旨在通过低频振幅（ALFF）方法评估阅读障碍（RD）患者自发脑活动的变化，并探讨其与临床行为表现的关系。
共招募20例RD患者（6例男性，14例女性）和20名健康对照者（HCs）（6例男性，14例女性），并在性别和年龄上进行匹配。所有参与者均完成功能磁共振成像（fMRI）扫描。我们应用ALFF方法检测自发脑活动。采用受试者工作特征（ROC）曲线区分RD患者与HCs。
与HCs相比，RD患者右侧枕叶和右侧额内侧回的ALFF值降低，右侧额眶上回和左侧颞下回的ALFF值升高。在RD患者中，我们未发现平均ALFF值与临床行为表现之间存在任何关系。
RD患者在视觉及与视觉相关的脑区表现出自发脑活动异常，这可能为探索RD患者急性视力丧失的潜在病理机制提供线索。
