Hubei Key Laboratory of Processing and Application of Catalytic Materials, College of Chemical Engineering, Huanggang Normal University, Huanggang City, Hubei Province, 438000, China.
School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
J Nanosci Nanotechnol. 2019 May 1;19(5):2453-2459. doi: 10.1166/jnn.2019.15884.
We developed a composite of graphene and poly(acrylic acid) (PAA) to build dissolving microneedles for potential transdermal drug delivery and photothermal therapy. The results showed that each microneedle array comprised 100 (10×10) pyramidal needles with a tip-to-tip distance of 500 m and height of 550 m. The graphene incorporation reinforced the mechanical strength of the microneedles and facilitated their insertion into the skin. Importantly, the graphene/PAA microneedles exhibited good photothermal effects under near-infrared (NIR) irradiation and rapid drug delivery behavior due to the good water solubility of the PAA matrix. Hence, the resulting graphene/PAA microneedles have great potential for application in synergistic chemo- and photothermal therapies for skin cancer.
我们开发了一种石墨烯和聚丙烯酸（PAA）的复合材料，用于构建用于潜在透皮药物输送和光热治疗的溶解微针。结果表明，每个微针阵列由 100 个（10×10）金字塔形针组成，针尖到针尖的距离为 500 m，高度为 550 m。石墨烯的掺入增强了微针的机械强度，并有助于其插入皮肤。重要的是，由于 PAA 基质具有良好的水溶性，石墨烯/PAA 微针在近红外（NIR）照射下表现出良好的光热效应和快速药物释放行为。因此，所得的石墨烯/PAA 微针在协同化学和光热治疗皮肤癌方面具有很大的应用潜力。
