Sirin Kose Seda, Atakul G, Asilsoy S, Uzuner N, Anal O, Karaman O
Dokuz Eylul University, Division of Pediatric Immunology and Allergy, Izmir, Turkey.
Dokuz Eylul University, Division of Pediatric Immunology and Allergy, Izmir, Turkey.
Allergol Immunopathol (Madr). 2019 May-Jun;47(3):265-271. doi: 10.1016/j.aller.2018.09.006. Epub 2018 Nov 27.
Symptom-based score (SBS) quantifies the number and severity of suspected cow's milk-related symptoms. In this study, we aimed to evaluate the efficiency of SBS in patients diagnosed with cow's milk protein (CMPA) and hen's egg allergy (HEA).
A single-center study was conducted between June 2015 and August 2017. Infants who were diagnosed with CMPA and HEA or both were enrolled in the study. SBS was applied at baseline and at one month during an elimination diet.
One hundred and twelve patients were enrolled in the study. Of these, 56 (50%) were female. Forty-nine (43.8%) patients were diagnosed with CMPA, 39 (34.8%) patients were diagnosed with HEA and 24 (21.4%) patients were diagnosed with cow's milk protein and hen's egg allergy (CMPHEA). In the analysis of SBS, median Bristol scale and initial total symptom-based scores were significantly lower in the HEA group than others (p=0.002; p=0.025). After the elimination diet, mean SBS decrease in the CMPHEA group (11.3±4.7) was found to be higher than CMPA (8.8±3.7) and HEA (8.0±4.0) groups (p=0.009). In 41 (83.7%) patients with CMPA, 33 (84.6%) patients with HEA and 21 (87.5%) patients with CMPHEA, a ≥50% decrease in SBS was observed after the elimination diet.
We may conclude that the present study suggests that SBS can be useful in monitoring the response to elimination diet in infants diagnosed with cow's milk protein and hen's egg allergy.
基于症状的评分（SBS）可量化疑似牛奶相关症状的数量和严重程度。在本研究中，我们旨在评估SBS在诊断为牛奶蛋白（CMPA）和鸡蛋过敏（HEA）患者中的有效性。
于2015年6月至2017年8月进行了一项单中心研究。诊断为CMPA和HEA或两者皆有的婴儿被纳入研究。在排除饮食的基线和一个月时应用SBS。
112名患者被纳入研究。其中，56名（50%）为女性。49名（43.8%）患者被诊断为CMPA，39名（34.8%）患者被诊断为HEA，24名（21.4%）患者被诊断为牛奶蛋白和鸡蛋过敏（CMPHEA）。在SBS分析中，HEA组的布里斯托量表中位数和初始基于症状的总分显著低于其他组（p = 0.002；p = 0.025）。排除饮食后，发现CMPHEA组的平均SBS降低值（11.3±4.7）高于CMPA组（8.8±3.7）和HEA组（8.0±4.0）（p = 0.009）。在41名（83.7%）CMPA患者、33名（84.6%）HEA患者和21名（87.5%）CMPHEA患者中，排除饮食后观察到SBS降低≥50%。
我们可以得出结论，本研究表明SBS可用于监测诊断为牛奶蛋白和鸡蛋过敏婴儿对排除饮食的反应。
