钙和乳制品的摄入与儿童肥胖以及脑源性神经营养因子反义（BDNF-AS）多态性的关系。

Association of calcium and dairy product consumption with childhood obesity and the presence of a Brain Derived Neurotropic Factor-Antisense (BDNF-AS) polymorphism.

机构信息

IMDEA-Food. CEI UAM+CSIC, Pabellón Central del Antiguo Hospital de Cantoblanco (Edificio nº 7), Crta. de Cantoblanco nº 8, 28049 Madrid, Spain.

IMDEA-Food. CEI UAM+CSIC, Pabellón Central del Antiguo Hospital de Cantoblanco (Edificio nº 7), Crta. de Cantoblanco nº 8, 28049 Madrid, Spain; Department of Production and Characterization of Novel Foods, Institute of Food Science Research (CIAL) CEI UAM+CSIC, Calle Nicolás Cabrera, 9, 28049 Madrid, Spain.

出版信息

Clin Nutr. 2019 Dec;38(6):2616-2622. doi: 10.1016/j.clnu.2018.11.005. Epub 2018 Nov 20.

DOI:10.1016/j.clnu.2018.11.005

PMID:30501916

Abstract

BACKGROUND & AIMS: Calcium and dairy products have multiple health benefits. The objective of this work was to evaluate the association between calcium/dairy intake, blood pressure, the BDNF-AS rs925946 polymorphism and nutritional status in a group of schoolchildren.

METHODS

As part of the GENYAL study to childhood obesity prevention, 221 children belonging to different areas of the Community of Madrid were enrolled. Anthropometric and dietary data were collected, and children were genotyped according to the rs925946 polymorphism. Adjusted logistic and linear models were used to describe the data.

RESULTS

A significantly lower consumption of calcium in overweight versus normal weight children was observed (811.0 ± 174.1; 859.0 ± 195.9; 954.0 ± 223.1 mg; for obesity, overweight and normal weight, respectively, p = 0.010). Moreover, an inverse association between blood pressures and calcium intake was detected (β = -0.006 (-0.011, -3e)), p = 0.040. The number of dairy servings/day showed a protective effect against overweight (OR = 0.48 (0.29, 0.75), p = 0.001). Finally, common homozygous children (GG) showed an inverse association between the calcium intake and the BMI (β = -0.003 (-0.006, -0.001), p = 0.004), which was not observed in children carrying the T allele (β = -1.3e (-0.0022, 0.0024), p = 0.93).

CONCLUSION

Calcium and dairy were strongly associated with the nutritional status and blood pressure. The identification of differential effects of calcium/dairy consumption on the nutritional status according to genetics may contribute to the personalization of future nutritional advice.

TRIAL REGISTRATION

This study is registered at www.clinicaltrials.govNCT03419520.

摘要

背景与目的

钙和乳制品对健康有多种益处。本研究旨在评估钙/乳制品摄入量、血压、BDNF-AS rs925946 多态性与营养状况之间的关系，研究对象为一组学童。

方法

作为马德里社区儿童肥胖预防 GENYAL 研究的一部分，共纳入 221 名来自不同地区的儿童。收集了他们的人体测量学和饮食数据，并根据 rs925946 多态性对儿童进行了基因分型。采用逻辑回归和线性模型对数据进行描述。

结果

超重儿童的钙摄入量显著低于正常体重儿童（811.0 ± 174.1；859.0 ± 195.9；954.0 ± 223.1 mg；肥胖、超重和正常体重组分别为 p = 0.010）。此外，还发现血压与钙摄入量呈负相关（β = -0.006（-0.011，-3e），p = 0.040）。每日乳制品摄入量与超重呈负相关（OR = 0.48（0.29，0.75），p = 0.001）。最后，常见纯合子儿童（GG）的钙摄入量与 BMI 呈负相关（β = -0.003（-0.006，-0.001），p = 0.004），而携带 T 等位基因的儿童则没有这种相关性（β = -1.3e（-0.0022，0.0024），p = 0.93）。