Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.
Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España; Facultad de Medicina, Universitat de València, Valencia, España.
Med Clin (Barc). 2019 Jun 21;152(12):488-492. doi: 10.1016/j.medcli.2018.09.018. Epub 2018 Nov 30.
Studies reporting incidences of non-melanoma skin cancer (NMSC) are heterogeneous, depend on the geographic area of the studied population and are often short-term. The aim of this study is to determine the incidence of NMSC in patients treated with oral PUVA therapy in the Mediterranean area.
A retrospective, observational study was carried out with a sample of 234 patients treated with systemic PUVA between 1982 and 1996, carrying out a historical follow-up until May 2017. The incidencedensity rate of CCNM (crude and adjusted) was calculated by direct standardisation. The incidence of CCNM was compared with that reported in the general population in a similar geographical area.
50 neoplasms were diagnosed in 22 patients. The prevalence of CCNM in patients treated with phototherapy was 10.3%. The mean follow-up time was 21 years. The crude-adjusted incidence density rate of CCNM was 554.4-183.9 cases/100,000 treated patients per year. The crude-adjusted incidence density rate of basal cell carcinoma was 352.3-111.2 cases/100.000 patients and of squamous cell carcinoma was 229-77.7 cases /100,000 patients.
PUVA therapy is associated with an increased risk of CCNM inthe Mediterranean population.
报告非黑色素瘤皮肤癌（NMSC）发病率的研究结果存在差异，取决于研究人群的地理位置，且往往是短期的。本研究旨在确定在接受口服 PUVA 治疗的地中海地区患者中 NMSC 的发病率。
对 1982 年至 1996 年间接受全身 PUVA 治疗的 234 例患者进行了回顾性、观察性研究，进行了截至 2017 年 5 月的历史随访。通过直接标准化计算 CCNM（原始和调整）的发病率密度率。将 CCNM 的发病率与类似地理区域的一般人群中的报告发病率进行比较。
22 例患者中诊断出 50 个肿瘤。接受光疗治疗的患者中 CCNM 的患病率为 10.3%。平均随访时间为 21 年。CCNM 的原始调整发病率密度率为 554.4-183.9 例/100,000 例/年。基底细胞癌的原始调整发病率密度率为 352.3-111.2 例/100,000 例，鳞状细胞癌为 229-77.7 例/100,000 例。
在地中海人群中，PUVA 治疗与 CCNM 的风险增加相关。
