Ribeiro R, Labareda J M, Garcia e Silva L
Servico de Dermatologia, Hospital de Santa Maria, Lisboa.
Med Cutan Ibero Lat Am. 1988;16(2):137-9.
A 52 year old housewife was vaccinated against smallpox at the age of 18, on her right deltoid area. At the age of 50 she noticed erythema and scaling on the vaccination scar and 2 years later a nodule appear that enlarged during the following 3 months. There was no history nor skin changes suggestive of significant sun exposure. The histological examination of an initial biopsy and of the subsequently excised lesion revealed a basal cell carcinoma of the solid type. The relevant literature was reviewed and discussed with emphasis on sex and age incidence, age and site of vaccination, free interval between inoculation and tumor appearance, coexistence or not of other sun induced neoplasias and precancerous lesions and other possibly relevant clinical and etiopathogenetic aspects.
一名52岁的家庭主妇18岁时在右三角肌区域接种了天花疫苗。50岁时，她注意到接种疤痕处出现红斑和脱屑，2年后出现一个结节，在接下来的3个月里逐渐增大。没有明显日晒史或提示显著日晒的皮肤变化。对最初活检以及随后切除病变的组织学检查显示为实体型基底细胞癌。对相关文献进行了综述和讨论，重点关注性别和年龄发病率、接种年龄和部位、接种与肿瘤出现之间的间隔时间、是否存在其他日光诱发的肿瘤和癌前病变以及其他可能相关的临床和病因学方面。
