锌指反义 1：一种在人类癌症中具有复杂作用的长非编码 RNA。

Zinc finger antisense 1: A long noncoding RNA with complex roles in human cancers.

机构信息

Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, China.

Department of General Surgery, The Fourth Hospital of China Medical University, Shenyang, China.

出版信息

Gene. 2019 Mar 10;688:26-33. doi: 10.1016/j.gene.2018.11.075. Epub 2018 Nov 29.

DOI:10.1016/j.gene.2018.11.075

PMID:30503395

Abstract

Zinc finger antisense 1 (ZFAS1), a newly identified long non-coding RNA, is a transcript antisense to the 5' end of the protein-coding gene zinc finger NFX1-type containing 1 which hosts three C/D-box small nucleolar RNAs (SNORDs) within sequential introns: Snord12, Snord12b, and Snord12c. ZFAS1 is dysregulated and acts as either an oncogene or a tumor suppressor in different human malignancies. ZFAS1 has been implicated in many aspects of carcinogenesis, including proliferation, invasion, metastasis, apoptosis, cell cycle, and drug resistance. The mechanisms underlying the effects of ZFAS1 are complex and involve multiple signaling pathways. In this review, the multiple pathological functions of ZFAS1 in diverse malignancies are systematically reviewed to elucidate the molecular basis of its biological roles and to provide new directions for future research.

摘要

锌指反义 1（ZFAS1）是一种新发现的长非编码 RNA，是锌指 NFX1 型蛋白编码基因 5'端的反义转录本，其中包含三个 C/D 框小核仁 RNA（SNORDs）：Snord12、Snord12b 和 Snord12c。ZFAS1 在不同的人类恶性肿瘤中失调并充当癌基因或肿瘤抑制基因。ZFAS1 参与了肿瘤发生的许多方面，包括增殖、侵袭、转移、凋亡、细胞周期和耐药性。ZFAS1 作用的机制复杂，涉及多个信号通路。在这篇综述中，我们系统地综述了 ZFAS1 在多种恶性肿瘤中的多种病理功能，以阐明其生物学作用的分子基础，并为未来的研究提供新的方向。