Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Department of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD 21201, USA.
Int J Mol Sci. 2023 Jun 16;24(12):10249. doi: 10.3390/ijms241210249.
Despite colorectal cancer remaining a leading worldwide cause of cancer-related death, there remains a paucity of effective treatments for advanced disease. The molecular mechanisms underlying the development of colorectal cancer include altered cell signaling and cell cycle regulation that may result from epigenetic modifications of gene expression and function. Acting as important transcriptional regulators of normal biological processes, zinc finger proteins also play key roles in regulating the cellular mechanisms underlying colorectal neoplasia. These actions impact cell differentiation and proliferation, epithelial-mesenchymal transition, apoptosis, homeostasis, senescence, and maintenance of stemness. With the goal of highlighting promising points of therapeutic intervention, we review the oncogenic and tumor suppressor roles of zinc finger proteins with respect to colorectal cancer tumorigenesis and progression.
尽管结直肠癌仍然是全球主要的癌症相关死亡原因，但对于晚期疾病仍然缺乏有效的治疗方法。结直肠癌发展的分子机制包括细胞信号转导和细胞周期调节的改变，这可能是由于基因表达和功能的表观遗传修饰。锌指蛋白作为正常生物过程的重要转录调节因子，在调节结直肠肿瘤发生的细胞机制中也起着关键作用。这些作用影响细胞分化和增殖、上皮-间充质转化、细胞凋亡、动态平衡、衰老和干细胞的维持。为了突出治疗干预的有希望的切入点，我们综述了锌指蛋白在结直肠癌发生和进展方面的致癌和肿瘤抑制作用。
