Sarlos Donat Peter, Banyai Daniel, Peterfi Lehel, Szanto Arpad, Kovacs Gyula
Department of Urology, Medical School, University of Pecs, Pecs, Hungary.
Department of Urology, Medical School, University of Pecs, Pecs, Hungary
Anticancer Res. 2018 Dec;38(12):6663-6667. doi: 10.21873/anticanres.13033.
BACKGROUND/AIM: The association of Wilms' tumor (WT), papillary renal cell tumor (PRCT) and mucinous tubular and spindle cell carcinoma (MTSCC) with embryonal rests has already been documented, but the cellular origin of metanephric adenoma (MA) is not yet known. The aim of this study was to understand their developmental evolution and find diagnostic markers.
CD57, KRT7, AMACR, SCEL, WT1 and CDH17 expression was analysed by immunohistochemistry in the four types of tumors and the associated pre-neoplastic lesions.
Immunohistochemistry was able to differentiate WT, MA, MTSCC and PRCT. A phenotypic correlation between MA and perilobar nephrogenic rest associated with WT was identified.
Perilobar nephrogenic rest and MA arise from differentiation arrested cells of the proximal domain of the S-shape body. We propose that WT1, MA, MTSCC and PRCT derive from different forms of maturation arrested embryonal rests.
背景/目的：肾母细胞瘤（WT）、乳头状肾细胞肿瘤（PRCT）和黏液性肾小管及梭形细胞癌（MTSCC）与胚胎残留的关联已有文献记载，但后肾腺瘤（MA）的细胞起源尚不清楚。本研究的目的是了解它们的发育演变并寻找诊断标志物。
采用免疫组织化学方法分析了四种肿瘤及其相关的肿瘤前病变中CD57、细胞角蛋白7（KRT7）、α-甲基酰基辅酶A消旋酶（AMACR）、鞘脂激活蛋白原（SCEL）、肾母细胞瘤蛋白1（WT1）和钙黏蛋白17（CDH17）的表达。
免疫组织化学能够区分WT、MA、MTSCC和PRCT。发现MA与WT相关的叶周肾源性残留之间存在表型相关性。
叶周肾源性残留和MA起源于S形体近端区域分化停滞的细胞。我们提出WT1、MA、MTSCC和PRCT起源于不同形式的成熟停滞胚胎残留。
