Oliva Delmy, Nilsson Mats, Strandéus Michael, Andersson Bengt-Åke, Sharp Lena, Laytragoon-Lewin Nongnit, Lewin Freddi
Department of Oncology, Ryhov County Hospital, Jönköping, Sweden
Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Anticancer Res. 2018 Dec;38(12):6763-6770. doi: 10.21873/anticanres.13047.
Adverse skin reactions during radiotherapy (RT) are common. The aim of this study was to explore whether genetic variation might be linked to acute radiation skin reactions (ARSR).
One hundred and nineteen women undergoing adjuvant RT for breast cancer were included. The symptoms of itching, burning and irritation were self-reported twice using the visual analogue scale. Assessments used the Radiation Therapy Oncology Group scoring system for acute RT skin reaction (RTOG scale). Blood-based single nucleotide polymorphism (SNP) analysis was performed. Thirty SNPs of well-defined functional genes were investigated.
All women were assessed with ARSR. After RT, the women self-reported itching (n=97), burning (n=64) and irritation (n=96). Two SNPs in X-Ray Repair Cross Complementing 2 gene (XRCC2) rs2040639 and interferon gamma (IFNG) rs2069705 genes were found to be associated with ARSR.
An association between two SNPs and ARSR was found. The possibility of using these SNPs as prognostic biomarkers for ARSR as tools to improve the care of patients needs further investigation.
放疗（RT）期间出现皮肤不良反应很常见。本研究的目的是探讨基因变异是否可能与急性放射性皮肤反应（ARSR）相关。
纳入119例接受乳腺癌辅助放疗的女性。使用视觉模拟量表让患者自行报告瘙痒、灼痛和刺激症状两次。评估采用放射治疗肿瘤学组急性放疗皮肤反应评分系统（RTOG量表）。进行基于血液的单核苷酸多态性（SNP）分析。研究了30个功能明确的基因的SNP。
对所有女性进行了ARSR评估。放疗后，患者自行报告瘙痒（n = 97）、灼痛（n = 64）和刺激（n = 96）。发现X射线修复交叉互补2基因（XRCC2）的rs2040639和干扰素γ（IFNG）的rs2069705基因中的两个SNP与ARSR相关。
发现两个SNP与ARSR之间存在关联。将这些SNP用作ARSR的预后生物标志物作为改善患者护理工具的可能性需要进一步研究。
