Ampil Federico, Sangster Guillermo, Caldito Gloria, Richards Troy, Ngo Yen, Kim Donghyun, Chu Quyen
Departments of Radiology, Neurology and Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Anticancer Res. 2018 Dec;38(12):6797-6800. doi: 10.21873/anticanres.13051.
BACKGROUND/AIM: Radiotherapy for carcinoma invasion of the sacrum (CIS) is an alternative treatment to surgery in patients with advanced, inoperable tumors or those not medically eligible for resection of the neoplasm. Herein we present an observational study of patients with imaging-confirmed CIS who were treated non-operatively with radiation.
A retrospective chart review of CIS patients treated with palliative radiotherapy (PR) during a 9-year period (2004-2013) was performed.
Six women and 13 men with an average age of 60 years took part in this study. Most patients (84%) exhibited extrasacral metastases. Primary tumors included lung (n=6), colorectal (n=6), breast (n=3), bladder or kidney (n=2), and liver carcinoma or a tumor in an unknown primary site (n=2). The mean follow-up time was 10 months with a 2-year survival rate of 9%. The majority (71%) of symptomatic patients obtained relief from pain following PR. Half of those individuals who were non-ambulatory prior to therapy regained mobility. There were no acute ill-effects or later complications after irradiation.
Despite the small cohort and poor overall survival rate, non-operative radiation treatment is a beneficial method of palliative care in patients with CIS.
背景/目的：对于骶骨癌浸润（CIS）患者，放射治疗是晚期无法手术的肿瘤患者或因医学原因无法切除肿瘤的患者的一种替代治疗方法。在此，我们对影像学确诊为CIS且接受非手术放疗的患者进行了一项观察性研究。
对9年期间（2004 - 2013年）接受姑息性放疗（PR）的CIS患者进行回顾性病历审查。
6名女性和13名男性参与了本研究，平均年龄为60岁。大多数患者（84%）出现骶骨外转移。原发肿瘤包括肺癌（n = 6）、结直肠癌（n = 6）、乳腺癌（n = 3）、膀胱癌或肾癌（n = 2）以及肝癌或原发部位不明的肿瘤（n = 2）。平均随访时间为10个月，2年生存率为9%。大多数有症状的患者（71%）在接受PR后疼痛得到缓解。治疗前不能行走的患者中有一半恢复了行动能力。放疗后无急性不良反应或后期并发症。
尽管样本量小且总体生存率低，但非手术放疗是CIS患者姑息治疗的一种有益方法。
