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本文引用的文献

1
Health systems development in Thailand: a solid platform for successful implementation of universal health coverage.泰国的卫生系统发展:成功实施全民健康覆盖的坚实平台。
Lancet. 2018 Mar 24;391(10126):1205-1223. doi: 10.1016/S0140-6736(18)30198-3. Epub 2018 Feb 1.
2
Cyanide poisoning in Thailand before and after establishment of the National Antidote Project.泰国在建立国家解毒项目前后的氰化物中毒情况。
Clin Toxicol (Phila). 2018 Apr;56(4):285-293. doi: 10.1080/15563650.2017.1370098. Epub 2017 Sep 5.
3
Drug shortages: Implications for medical toxicology.药品短缺:对医学毒理学的影响。
Clin Toxicol (Phila). 2015 Jul;53(6):519-24. doi: 10.3109/15563650.2015.1043441. Epub 2015 May 8.
4
The use of economic evaluation for guiding the pharmaceutical reimbursement list in Thailand.在泰国,运用经济评估来指导药品报销目录。
Z Evid Fortbild Qual Gesundhwes. 2014;108(7):397-404. doi: 10.1016/j.zefq.2014.06.017. Epub 2014 Aug 23.
5
Antidotes: Where are they when needed?解毒剂:在需要时它们在哪里?
J Pharmacol Pharmacother. 2014 Jan;5(1):1-3. doi: 10.4103/0976-500X.124403.
6
Antidotes and their availability in South Africa.解毒剂及其在南非的可获取情况。
Clin Toxicol (Phila). 2009 Jan;47(1):77-80. doi: 10.1080/15563650701877366.
7
Human poisoning in Thailand: The Ramathibodi Poison Center's experience (2001-2004).泰国的人体中毒事件:拉玛蒂博迪中毒控制中心的经验(2001 - 2004年)
Clin Toxicol (Phila). 2007 Jun-Aug;45(5):582-8. doi: 10.1080/15563650701382789.

改善抗毒血清和抗蛇毒血清的可及性,泰国。

Improving access to antidotes and antivenoms, Thailand.

机构信息

National Health Security Office, Bangkok, Thailand.

Faculty of Medicine, Ramathibodi Hospital, 270 Rama 6 Road, Thung Phayathai Subdistrict, Ratchathewi District, Bangkok, 10400, Thailand.

出版信息

Bull World Health Organ. 2018 Dec 1;96(12):853-857. doi: 10.2471/BLT.18.217075. Epub 2018 Oct 29.

DOI:10.2471/BLT.18.217075
PMID:30505033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6249700/
Abstract

PROBLEM

Historically in Thailand, access to poison antidotes was limited and antivenom stock management was inefficient.

APPROACH

In 2010, the country established a national antidote programme, which created national and subnational antidote stocks, managed their distribution and trained health-care providers on clinical management and antidote use. In 2013, the programme incorporated antivenoms to improve stock management and avoid wastage due to stock expiry.

LOCAL SETTING

Before the programme, health-care providers consulted poison centres on clinical management of poisoning and some antidotes were not available. Individual hospitals stocked antivenoms, which often expired before use.

RELEVANT CHANGES

Today, the National Health Security Office finances and manages the centralized procurement of antidotes and antivenoms and all Thai patients have a right to antidotes regardless of health insurance. National and subnational stock levels are determined based on demand, treatment urgency and cost. A web-based system, which incorporates geographical information, was introduced for requesting antidotes and antivenoms. Poison centres provide training, 24-hour consultation services and outcome monitoring. Antidotes and antivenoms are now readily available and used correctly and clinical management has improved. Moreover, better stock and distribution control has helped avoid antivenom wastage and reduced antivenom costs, from US$ 2.23 million United States dollars (US$) to US$ 1.2 million.

LESSONS LEARNT

The programme's success depended on strong and sustained policy support, adequate funding, improved operational capacity, training for health-care professionals and the provision of 24-hour online consultation services. A web-based centralized procurement and distribution ensured these essential medicines were available, minimized costs, reduced waste and saved lives.

摘要

问题

在泰国历史上,获取解毒剂的途径有限,抗蛇毒血清的库存管理效率低下。

方法

2010 年,该国建立了国家解毒剂方案,创建了国家和国家以下各级解毒剂库存,管理其分发,并培训医疗保健提供者进行临床管理和解毒剂使用。2013 年,该方案纳入了抗蛇毒血清,以改善库存管理,避免因库存过期而造成浪费。

当地情况

在该方案实施之前,医疗保健提供者就中毒的临床管理向中毒中心咨询,一些解毒剂无法获得。个别医院储存抗蛇毒血清,这些血清往往在使用前过期。

相关变化

如今,国家卫生安全办公室为解毒剂和抗蛇毒血清的集中采购提供资金并进行管理,所有泰国患者都有权获得解毒剂,无论其是否有医疗保险。国家和国家以下各级的库存水平是根据需求、治疗紧迫性和成本确定的。引入了一个包含地理信息的基于网络的系统,用于请求解毒剂和抗蛇毒血清。中毒中心提供培训、24 小时咨询服务和结果监测。解毒剂和抗蛇毒血清现在随时可用,使用正确,临床管理得到改善。此外,更好的库存和分发控制有助于避免抗蛇毒血清浪费,并降低抗蛇毒血清成本,从 223 万美元降至 120 万美元。

经验教训

该方案的成功取决于强有力和持续的政策支持、充足的资金、运营能力的提高、医疗保健专业人员的培训以及提供 24 小时在线咨询服务。基于网络的集中采购和分发确保了这些基本药物的供应,最大限度地降低了成本,减少了浪费,挽救了生命。