Stoĭka R S, Kusen' S I
Ontogenez. 1988 May-Jun;19(3):229-39.
Data about polypeptide growth factors in animal cells during embryogenesis and about the sensitivity of these cells to regulatory effect of the factors have been systematically reviewed. The conclusion was drawn that they play an important role in molecular mechanisms controlling cell proliferation and differentiation at the early embryonic stages. Information has also been provided about transforming growth factors and about the products of some proto-oncogenes, which are detected in the embryonic cells in amounts comparable with those in the transformed cells. However, this does not lead to malignant growth. Moreover, microenvironment of an intact embryo exerts an antitransforming influence on tumor cells. Studies of the "normalizing" effect of the embryonic cells may help in developing new methods of suppression of the malignant growth.
关于胚胎发生过程中动物细胞内多肽生长因子以及这些细胞对因子调节作用敏感性的数据已得到系统综述。得出的结论是，它们在胚胎早期阶段控制细胞增殖和分化的分子机制中发挥重要作用。还提供了有关转化生长因子以及一些原癌基因产物的信息，这些在胚胎细胞中的检测量与转化细胞中的相当。然而，这并不会导致恶性生长。此外，完整胚胎的微环境对肿瘤细胞具有抗转化影响。对胚胎细胞“归一化”作用的研究可能有助于开发抑制恶性生长的新方法。
