Serdarevic O N, Hanna K, Gribomont A C, Savoldelli M, Renard G, Pouliquen Y
Manhattan Eye, Ear and Throat Hospital, Columbia University, New York.
Ophthalmology. 1988 Apr;95(4):493-505. doi: 10.1016/s0161-6420(88)33160-x.
The imprecision of trephination of donor and recipient corneas is a major factor in post-keratoplasty astigmatism. In order to improve the quality of trephination, the authors developed a rotating slit delivery system for noncontact penetrating keratoplasty trephination using the excimer laser at 193 nm. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and light microscopy (LM) demonstrated the superior quality of excimer-cut buttons and recipient beds as compared with those obtained by free hand and suction trephines in human cadaver and rabbit eyes. The laser trephined more regularly and precisely without distortion of corneal topography and with less damage to adjacent corneal tissue. The authors morphologically examined wound healing at 6 hours, 12 hours, 3 days, 5 days, 2 weeks, 2 months, and 3 months after penetrating keratoplasty with laser and mechanical trephination in an animal autograft model. The laser did not cause any adverse alteration of wound healing processes including cellular migration, proliferation, and production of new tissue.
供体和受体角膜环钻术的不精确性是角膜移植术后散光的一个主要因素。为了提高环钻术的质量，作者开发了一种旋转裂隙输送系统，用于使用193nm准分子激光进行非接触穿透性角膜移植环钻术。扫描电子显微镜（SEM）、透射电子显微镜（TEM）和光学显微镜（LM）显示，与在人尸体和兔眼中用徒手和抽吸环钻获得的相比，准分子激光切割的植片和受体床质量更优。激光环钻更规则、精确，不会使角膜地形图变形，对相邻角膜组织的损伤更小。作者在动物自体移植模型中，对激光和机械环钻穿透性角膜移植术后6小时、12小时、3天、5天、2周、2个月和3个月的伤口愈合进行了形态学检查。激光不会引起伤口愈合过程的任何不良改变，包括细胞迁移、增殖和新组织的产生。
