Skoner D, Caliguiri L
University of Pittsburgh School of Medicine, Pennsylvania.
Pediatr Clin North Am. 1988 Oct;35(5):1011-30. doi: 10.1016/s0031-3955(16)36545-2.
In summary, wheezing is a common manifestation of viral respiratory tract disease in infancy. The precise pathogenetic mechanisms of virus-induced wheezing and its sequelae are not clear, although recent reports about participation of the cellular and humoral immune systems are promising. Although therapies like those used to treat asthma are employed in the treatment of virus-induced wheezing in infancy, their efficacy remains controversial in bronchiolitis. Recently developed agents with antiviral properties are promising and the choice of any of these agents in a therapeutic regimen should be individualized. Antiviral agents during acute infections may modify the long-term sequelae. Clearly, much work needs to be done to elucidate pathogenetic mechanisms, and to develop new, safe, and effective anti-inflammatory agents for the therapy of these disorders.
总之，喘息是婴儿期病毒性呼吸道疾病的常见表现。尽管最近有关细胞和体液免疫系统参与的报道很有前景，但病毒诱导的喘息及其后遗症的确切发病机制尚不清楚。虽然用于治疗哮喘的疗法也用于治疗婴儿期病毒诱导的喘息，但其在治疗细支气管炎方面的疗效仍存在争议。最近开发的具有抗病毒特性的药物很有前景，在治疗方案中选择任何一种此类药物都应个体化。急性感染期间使用抗病毒药物可能会改变长期后遗症。显然，需要做大量工作来阐明发病机制，并开发新的、安全有效的抗炎药物来治疗这些疾病。
