Chen Wu-Fu, Chang Yu-Chia, Chiu Yuh-Wen, Fang Lee-Shing, Chen Yu-Hsin, Su Yin-Di, Peng Bo-Rong, Lu Mei-Chin, Chen Jih-Jung, Wen Zhi-Hong, Wu Yang-Chang, Sung Ping-Jyun
Nat Prod Commun. 2016 Dec;11(12):1783-1784.
A natural caulerpenyne-derived sesquiterpene, oxytoxin-2 (1), was isolated from a cultured mollusc Volvatella vigourouxi. The structure of 1 was elucidated on the basis of spectroscopic analysis and this compound was suggested to be a diet-derived metabolite from the green alga Caulerpa sertularioides.-This is the first study on the chemical constituents of V. vigourouxi. Oxytoxin-2 (1) was found to inhibit significantly the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
从养殖的软体动物强壮旋鳃虫（Volvatella vigourouxi）中分离出一种天然的源自蕨藻素的倍半萜烯——氧化毒素-2（1）。基于光谱分析阐明了1的结构，并且该化合物被认为是来自绿藻粗枝软骨藻（Caulerpa sertularioides）的饮食衍生代谢物。——这是对强壮旋鳃虫化学成分的首次研究。发现氧化毒素-2（1）能显著抑制脂多糖（LPS）刺激的RAW264.7巨噬细胞中促炎诱导型一氧化氮合酶（iNOS）蛋白的表达。
