Psychiatry Res. 2019 Jan;271:259-264. doi: 10.1016/j.psychres.2018.11.033. Epub 2018 Nov 16.
Obsessive-compulsive disorder (OCD) is a highly disabling psychiatric disorder characterized by recurrent obsessions and compulsions. It has a lifetime prevalence of 1-3% in the general population and commonly has a chronic course. First-line treatments consist of selective serotonin reuptake inhibitors and cognitive-behavioral therapy but up to 60% of patients respond partially or not at all to these treatments. This paper reviewed the literature on the safety and efficacy of transcranial direct current stimulation (tDCS) for the treatment of obsessive-compulsive disorder and discussed future directions for research and clinical application. Criteria for inclusion were open or controlled studies on tDCS and OCD that used validated rating scales along with well-described stimulus parameters. In the majority of the limited number of published studies, most patients with treatment-resistant obsessive-compulsive disorder had either moderate or marked benefit with this technique different stimulation targets, sometimes sustained for many months. This technique might be efficacious in the treatment of obsessive-compulsive disorder, although it is difficult to draw definitive conclusions about its efficacy, future well-designed sham-controlled studies are needed to confirm the safety and efficacy of tDCS for the treatment of this condition.
强迫症（OCD）是一种高度致残的精神障碍，其特征是反复出现的强迫观念和强迫行为。在普通人群中，其终身患病率为 1-3%，且通常具有慢性病程。一线治疗包括选择性 5-羟色胺再摄取抑制剂和认知行为疗法，但多达 60%的患者对这些治疗反应部分或完全不反应。本文回顾了经颅直流电刺激（tDCS）治疗强迫症的安全性和疗效的文献，并讨论了未来研究和临床应用的方向。纳入标准为使用经过验证的评定量表和描述良好的刺激参数的关于 tDCS 和 OCD 的开放性或对照研究。在已发表的数量有限的研究中，大多数对治疗抵抗性强迫症患者进行治疗后，大多数患者均从中获得了中度或显著获益，不同的刺激靶点，有时可持续数月。虽然 tDCS 治疗强迫症可能有效，但由于其疗效难以得出明确结论，未来需要进行精心设计的假刺激对照研究，以确认 tDCS 治疗这种疾病的安全性和疗效。
