卡托普利对慢性阻塞性肺疾病合并继发性肺动脉高压患者的影响。
Effects of captopril in patients with chronic obstructive pulmonary disease and secondary pulmonary hypertension.
作者信息
Patakas D, Georgopoulos D, Rodini H, Christaki P
机构信息
Department of Internal Medicine, University of Thessaloniki, Greece.
出版信息
Postgrad Med J. 1988 Mar;64(749):193-5. doi: 10.1136/pgmj.64.749.193.
Abstract
Ten patients with chronic obstructive pulmonary disease (COPD) with normal left ventricular function were given a single dose of captopril (0.25 mg/kg). Mean systemic arterial pressure, heart rate and coronary flow to the right ventricle were reduced significantly after captopril. In contrast captopril did not cause a significant fall in pulmonary arterial pressure or pulmonary vascular resistance. We conclude that captopril fails to produce haemodynamic benefits in such hypoxic patients and that angiotensin II is not playing a significant role in maintaining pulmonary vasoconstriction.
摘要
对10名左心室功能正常的慢性阻塞性肺疾病（COPD）患者给予单剂量卡托普利（0.25毫克/千克）。给予卡托普利后，平均体动脉压、心率和右心室冠状动脉血流量显著降低。相比之下，卡托普利并未导致肺动脉压或肺血管阻力显著下降。我们得出结论，卡托普利在此类缺氧患者中未能产生血流动力学益处，且血管紧张素II在维持肺血管收缩方面未发挥重要作用。
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Feline hypoxic pulmonary vasoconstriction is not blocked by the angiotensin I-converting enzyme inhibitor, captopril.猫的低氧性肺血管收缩不受血管紧张素I转换酶抑制剂卡托普利的阻断。
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