Department of Rheumatology - MRB2, Ghent University Hospital, Corneel Heymanslaan 10, BE-9000, Ghent, Belgium; VIB Center for Inflammation Research, Ghent University, Ghent, Belgium.
Best Pract Res Clin Rheumatol. 2017 Dec;31(6):887-894. doi: 10.1016/j.berh.2018.07.011. Epub 2018 Sep 1.
Spondyloarthritis (SpA) refers to a group of chronic inflammatory arthritic diseases that can be severely debilitating. The most common form of SpA affecting the peripheral skeleton is psoriatic arthritis, while that affecting the axial skeleton is ankylosing spondylitis. SpA has a multifactorial nature, with both genetic and environmental factors initiating and maintaining the disease. Recently, the role of biomechanical stress as an initiator of disease has gained much attention, with efforts focusing on the underlying cellular and molecular mechanisms. In this review, we provide a different view, with emphasis on the apparently contradictory role of physical therapy in SpA owing to the impact of biomechanical stress and put this in an evolutionary context due to changes in environment and lifestyle across time.
脊柱关节炎（SpA）是一组慢性炎症性关节疾病，可导致严重的身体残疾。影响外周骨骼的最常见 SpA 形式是银屑病关节炎，而影响中轴骨骼的是强直性脊柱炎。SpA 具有多因素性质，遗传和环境因素都可引发和维持疾病。最近，生物力学应激作为疾病的启动因素的作用引起了广泛关注，研究重点是潜在的细胞和分子机制。在这篇综述中，我们提供了一个不同的观点，强调了由于生物力学应激的影响，物理治疗在 SpA 中的明显矛盾作用，并从环境和生活方式随时间变化的角度将其置于进化背景下进行讨论。
