曲霉二酮哌嗪-2a 的异源生产：真菌特异性 DUF3328 氧化酶进行顺序氧化大环化的建议。
Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase.
机构信息
Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Hokkaido, Japan.
出版信息
Org Biomol Chem. 2018 Dec 19;17(1):39-43. doi: 10.1039/c8ob02824a.
PMID:30516224
Abstract
Asperipin-2a is a ribosomally synthesized and post-translationally modified peptide isolated from Asperigillus flavus. Herein, we report the heterologous production of asperipin-2a and determination of its absolute structure. Notably, the characteristic bicyclic structure was likely constructed by a single oxidase containing the DUF3328 domain.
摘要
黄曲霉来源的核糖体合成后修饰肽asperipin-2a 的异源表达及其绝对构型确定。该化合物的特征双环骨架结构可能由一个含有 DUF3328 结构域的单氧化酶构建。
Zotero 插件