一种性排斥肽：控制小鼠种群过剩的潜在用途。

A sexual rejection peptide: potential use for controlling mouse overpopulation.

作者信息

Osakada Takuya, Itakura Takumi, Kenmochi Ryo, Touhara Kazushige

机构信息

a Department of Applied Biological Chemistry , Graduate School of Agricultural and Life Sciences, The University of Tokyo , Tokyo , Japan.

b ERATO Touhara Chemosensory Signal Project, JST , The University of Tokyo , Tokyo , Japan.

出版信息

Biosci Biotechnol Biochem. 2019 Apr;83(4):705-708. doi: 10.1080/09168451.2018.1554427. Epub 2018 Dec 5.

DOI:10.1080/09168451.2018.1554427

PMID:30516446

Abstract

Exocrine gland-secreting peptide 22 (ESP22) is a 10-kDa protein secreted in tears of juvenile mice. ESP22 inhibits sexual behaviors in adults, leading to a reduction in reproduction rate. We herein identified the 24 amino acid sequence within ESP22 that was essential for exhibiting sexual rejection activity. This synthesizable peptide can be useful for controlling mouse overpopulation.

摘要

外分泌腺分泌肽22（ESP22）是一种在幼年小鼠泪液中分泌的10千道尔顿蛋白质。ESP22抑制成年小鼠的性行为，导致繁殖率降低。我们在此确定了ESP22中对于表现出性排斥活性至关重要的24个氨基酸序列。这种可合成的肽可用于控制小鼠数量过多的问题。