Medicina Vascolare e D'Urgenza-Stroke Unit, Ospedale Santa Maria della Misericordia, Università di Perugia, Perugia, Italy.
Curr Opin Neurol. 2019 Feb;32(1):36-42. doi: 10.1097/WCO.0000000000000643.
The absolute risk of pregnancy-associated intracranial haemorrhage (ICH) has been reported to be relatively low and often associated with high risks of life-long disabilities and mortality. The aim of this narrative review was obtaining a better understanding of the current management practices for ICH, unruptured aneurysms and/or arteriovenous malformations during pregnancy, as well as the effects of future pregnancies, and the uses of oral contraceptive or HRT.
General guidelines for the management of ICH are used for pregnant women but additional expedient and thorough evaluation of foetal viability and its gestational age are requested. Recent epidemiological data suggest that menopause can be an independent risk factor for the development of aneurysmal subarachnoid haemorrhage. Furthermore, several population-based studies performed on women with aneurysmal subarachnoid haemorrhage observed a lower risk of bleeding with HRT.
The current review observed that the management practices for ICH during pregnancy were seen to be somewhat uniform. Whereas, the practices regarding future pregnancies and the prescriptions of either oral contraceptives or HRT do not follow coherent patterns. In light of this, we recommend the establishment of an international registry that would collect data on women with ICH during pregnancy.
妊娠相关颅内出血(ICH)的绝对风险相对较低,常伴有终身残疾和死亡率高的风险。本综述的目的是更好地了解妊娠期间 ICH、未破裂动脉瘤和/或动静脉畸形的当前治疗方法,以及未来妊娠的影响,以及口服避孕药或 HRT 的使用。
一般 ICH 管理指南用于孕妇,但需要对胎儿存活及其胎龄进行额外的紧急和彻底评估。最近的流行病学数据表明,绝经可能是蛛网膜下腔出血的独立危险因素。此外,对蛛网膜下腔出血的女性进行的几项基于人群的研究观察到,HRT 出血风险较低。
目前的综述观察到,妊娠期间 ICH 的治疗方法似乎有些统一。然而,关于未来妊娠和口服避孕药或 HRT 处方的做法并没有遵循一致的模式。有鉴于此,我们建议建立一个国际登记处,收集妊娠期间 ICH 女性的数据。