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[用于检测人类免疫缺陷病毒抗原和抗体的免疫酶法及其在不同人群血清学检测中的应用]

[Immunoenzyme method for demonstrating the antigen and antibodies to the human immunodeficiency virus and its use for the serological examination of different population groups].

作者信息

Zhdanov V M, Karamov E V, Arakelov S A, Rudneva I A, Ketiladze E S

出版信息

Vopr Virusol. 1988 May-Jun;33(3):294-8.

PMID:3051666
Abstract

An enzyme immune diagnosticum for the detection of the antigen and antibody to human immunodeficiency virus (HIV) has been developed at D. I. Ivanovskiĭ Institute of Virology of the USSR AMS. The method is based on the principle of competitive analysis using an antiviral conjugate which allows the sera to be tested without preliminary dilution and ensures a high sensitivity of the diagnosticum. The survey for HIV antibody covered 5743 subjects, among them 4898 Soviet citizens predominantly belonging to high risk groups of contracting AIDS infection, and 845 foreigners. No antibody to HIV has been detected in any of the Soviet citizens. Among the foreigners, antibody to HIV were detected in 6 subjects, all of them arriving from different African countries.

摘要

苏联医学科学院D. I. 伊万诺夫斯基病毒学研究所研制出一种用于检测人类免疫缺陷病毒(HIV)抗原和抗体的酶免疫诊断试剂。该方法基于竞争分析原理,使用抗病毒缀合物,无需对血清进行预稀释即可进行检测,并确保诊断试剂具有高灵敏度。对HIV抗体的调查涵盖了5743名受试者,其中4898名苏联公民主要属于感染艾滋病的高危人群,845名外国人。在任何一名苏联公民中均未检测到HIV抗体。在外国人中,有6名受试者检测到HIV抗体,他们均来自不同的非洲国家。

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