18F-胆碱 PET/CT 偶然发现前列腺癌甲状腺内转移。

Incidental Finding of Intrathyroid Metastases of Prostatic Cancer on 18F-Choline PET/CT.

机构信息

Pathology Department, CHU Toulouse.

Oncology Department, Institut Universitaire de Cancérologie-Oncopole, Institut Claudius Regaud, Toulouse, France.

出版信息

Clin Nucl Med. 2019 Feb;44(2):e101-e103. doi: 10.1097/RLU.0000000000002374.

DOI:10.1097/RLU.0000000000002374

PMID:30516690

Abstract

An 85-year-old man with a 2-year history of prostate cancer, treated with radiotherapy and hormonal therapy, presented increased prostatic-specific antigen levels. F-choline PET/CT showed focal prostatic uptake consistent with known local recurrence, increased uptake of 2 hypodense thyroid nodules and of 2 left cervical lymph nodes, suspected as thyroid cancer. Neck ultrasound confirmed the high risk of malignancy, and a guided biopsy (of a thyroid nodule and cervical lymph node) revealed cellular infiltrates thyroid transcription factor-1 (TTF-1) negative and prostatic-specific antigen positive, confirming intrathyroid and cervical lymph node metastases of prostate cancer. PET/CT changed the disease staging. Chemotherapy was initiated.

摘要

一位 85 岁男性，患有前列腺癌 2 年，曾接受过放疗和激素治疗，前列腺特异抗原水平升高。氟代胆碱 PET/CT 显示局灶性前列腺摄取，与已知的局部复发一致，同时还显示 2 个低密甲状腺结节和 2 个左侧颈部淋巴结摄取增加，提示甲状腺癌。颈部超声证实了高度恶性的可能性，引导活检（甲状腺结节和颈部淋巴结）显示细胞浸润，甲状腺转录因子-1（TTF-1）阴性，前列腺特异抗原阳性，证实前列腺癌甲状腺内和颈部淋巴结转移。PET/CT 改变了疾病分期。开始进行化疗。