Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, College of Veterinary Medicine, Ames, Iowa, 50011.
Interdepartmental Microbiology, Iowa State University, Ames, Iowa, 50011.
J Eukaryot Microbiol. 2019 Jul;66(4):684-688. doi: 10.1111/jeu.12706. Epub 2019 Jan 11.
We report that the gold containing antirheumatoid drug auranofin is amoebicidal against human pathogenic Naegleria fowleri. Treatment of N. fowleri cultures at biologically relevant concentrations of 0.75-3.0 μg/ml auranofin reduced amoeba counts, metabolic activity, and increased cell permeability. These results suggest that the addition of auranofin may benefit the treatment of N. fowleri-infected patients afflicted by the rapidly fatal disease primary amoebic meningoencephalitis.
我们报告称，含金的抗风湿药物金诺芬对人类致病性福氏耐格里阿米巴具有杀阿米巴作用。在生物学相关浓度为 0.75-3.0μg/ml 的金诺芬处理福氏耐格里阿米巴培养物可降低阿米巴计数、代谢活性并增加细胞通透性。这些结果表明，添加金诺芬可能有益于治疗因原发性阿米巴脑膜脑炎这一迅速致命疾病而感染福氏耐格里阿米巴的患者。
