Nanjing University of Science & Technology, China.
J Atten Disord. 2021 Jan;25(2):258-264. doi: 10.1177/1087054718816170. Epub 2018 Dec 6.
In this study, we investigate the brain lateralization in ADHD patients. Furthermore, we also explore the difference between male and female patients, and the difference among distinct ADHD subtypes, that is, ADHD-inattentive (ADHD-IA) and ADHD-combined (ADHD-C). We employed the standard deviation to quantify the variability of resting-state functional magnetic resonance imaging (fMRI) signal and measure the lateralization index (LI). ADHD patients showed significantly increased rightward lateralization in the inferior frontal gyrus (opercular), precuneus, and paracentral lobule, and decreased rightward lateralization in the insula. Compared with male patients, female patients showed significantly rightward lateralization in the putamen and lobule VII of cerebellar hemisphere. ADHD-C patients exhibited increased rightward lateralization in the inferior frontal gyrus (opercular), and decreased rightward lateralization in the inferior temporal gyrus, as compared with ADHD-IA. The LI was also found to be related to inattentive and hyper/impulsive scores. These key findings may aid in understanding the pathology of ADHD.
在这项研究中，我们调查了 ADHD 患者的大脑侧化。此外，我们还探讨了男女性别患者之间的差异，以及不同 ADHD 亚型之间的差异，即注意力不集中型 ADHD（ADHD-IA）和注意力缺陷多动混合型 ADHD（ADHD-C）。我们采用标准差来量化静息态功能磁共振成像（fMRI）信号的变异性，并测量侧化指数（LI）。ADHD 患者的额下回（脑岛盖部）、楔前叶和顶下小叶的右侧化显著增加，而脑岛的右侧化显著减少。与男性患者相比，女性患者的壳核和小脑半球第七小叶的右侧化显著增加。与 ADHD-IA 相比，ADHD-C 患者的额下回（脑岛盖部）右侧化增加，而颞下回的右侧化减少。LI 也与注意力不集中和多动/冲动评分相关。这些关键发现可能有助于理解 ADHD 的病理。
