Pirau Letitia, Lui Forshing
California Northstate University
CA Northstate Uni, College of Med
Although the etiology is unknown, sarcoidosis is a systemic disease that results in the formation of granulomas. Classically, the granulomas in sarcoidosis are non-caseating granulomas, which may be found throughout lymph nodes and organs, including the brain and nervous system. About 5% to 10% of patients with sarcoidosis will have neurologic complications. Although the majority of patients with sarcoidosis do not have symptoms, neurosarcoidosis may be life-threatening and tends to occur in cases with systemic involvement. Neurosarcoidosis tends to occur in patients who have systemic features and active disease. The diagnosis of neurosarcoidosis is difficult and usually one of exclusion. Sometimes a nerve or muscle biopsy may reveal a non-caseating granuloma. There is no cure for neurosarcoidosis. Most patients require long-term treatment with corticosteroids.
尽管病因不明，但结节病是一种导致肉芽肿形成的全身性疾病。典型地，结节病中的肉芽肿为非干酪样肉芽肿，可在包括脑和神经系统在内的淋巴结及器官中发现。约5%至10%的结节病患者会出现神经并发症。尽管大多数结节病患者没有症状，但神经结节病可能危及生命，且往往发生在有全身受累的病例中。神经结节病倾向于发生在具有全身特征和活动性疾病的患者中。神经结节病的诊断困难，通常是排除性诊断。有时神经或肌肉活检可能显示非干酪样肉芽肿。神经结节病无法治愈。大多数患者需要长期使用皮质类固醇进行治疗。
