Mubarik Ateeq, Iqbal Arshad Muhammad
Oak hill hospital
Oak Hill Hospital, Brooksville, FL
Loeffler endocarditis is an eosinophilic-mediated restrictive cardiomyopathy occurring as part of the spectrum of hypereosinophilic syndromes. First described by W. Loeffler in 1936, Loeffler endocarditis is associated with peripheral eosinophilia and is one of the rare complications of hypereosinophilic syndromes. Extensive eosinophilic infiltration and damage to multiple organs characterize hypereosinophilic syndromes. Loeffler endocarditis results in impaired heart relaxation with impaired diastolic filling. The predominant pathology of Loeffler endocarditis is diffuse eosinophilic infiltration of the myocardium. Cardinal manifestations of Loeffler endocarditis include left or right heart failure, thromboembolic events (stroke, limb ischemia, renal infarction), or arrhythmia. Life-threatening clinical presentations warrant immediate initiation of therapy, including steroids or immunosuppressive therapy. Eosinophilic endomyocardial disease or fibroblastic endocarditis can be used interchangeably for Loeffler endocarditis. Endomyocardial fibrosis is a disease closely resembling the late stage of Loeffler endocarditis.
吕弗勒心内膜炎是一种嗜酸性粒细胞介导的限制性心肌病，是嗜酸性粒细胞增多综合征谱系的一部分。1936年由W. 吕弗勒首次描述，吕弗勒心内膜炎与外周嗜酸性粒细胞增多有关，是嗜酸性粒细胞增多综合征的罕见并发症之一。嗜酸性粒细胞增多综合征的特征是广泛的嗜酸性粒细胞浸润和多器官损害。吕弗勒心内膜炎导致心脏舒张功能受损，舒张期充盈受损。吕弗勒心内膜炎的主要病理表现为心肌弥漫性嗜酸性粒细胞浸润。吕弗勒心内膜炎的主要表现包括左心或右心衰竭、血栓栓塞事件（中风、肢体缺血、肾梗死）或心律失常。危及生命的临床表现需要立即开始治疗，包括使用类固醇或免疫抑制疗法。嗜酸性粒细胞性心内膜疾病或纤维母细胞性心内膜炎可与吕弗勒心内膜炎互换使用。心内膜纤维化是一种与吕弗勒心内膜炎晚期非常相似的疾病。
