赭曲霉毒素A对大鼠晶状体影响的研究。

Studies on the influence of ochratoxin A on rat lenses.

作者信息

Rankov B G, Tomova S

出版信息

Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Jan 31;205(2):135-9. doi: 10.1007/BF00410108.

Abstract

The influence of ochratoxin A on enzyme activities and on the content of free adenine nucleotides and intermediates of glycolysis in rat lenses was investigated. For a period of eight weeks, five times weekly, albino Wistat rats received ochratoxin A in 0.1% NaHCO3, dosed 1/100 LD50, via stomach tube. All measurements were made at the end of the experiment. Decreased contents of ATP, G-6-P, sum of fructose, and F-6-P were observed, but pyruvic acid, AMP, and DAP increased. Relatively decreased activities of enzymes MDH, ALD, HK, GK, and PK were established. The influence of ochratoxin A on the carbohydrate metabolism of rat lenses with respect to tranparency is discussed. There were no significant differences in absolute lens weight in animals treated by ochratoxin A and controls.

摘要

研究了赭曲霉毒素A对大鼠晶状体中酶活性、游离腺嘌呤核苷酸含量以及糖酵解中间产物的影响。在八周的时间里，白化Wistat大鼠每周五次通过胃管接受溶于0.1% NaHCO₃的赭曲霉毒素A，剂量为1/100 LD₅₀。所有测量均在实验结束时进行。观察到ATP、G-6-P、果糖总和以及F-6-P的含量降低，但丙酮酸、AMP和DAP增加。确定了MDH、ALD、HK、GK和PK等酶的活性相对降低。讨论了赭曲霉毒素A对大鼠晶状体碳水化合物代谢透明度的影响。接受赭曲霉毒素A处理的动物与对照组在晶状体绝对重量上没有显著差异。