a Department of Neurology, School of Medicine , University of California, Davis , Sacramento , CA , USA.
Expert Opin Investig Drugs. 2019 Feb;28(2):191-205. doi: 10.1080/13543784.2019.1557147. Epub 2018 Dec 13.
Neuroinflammation has a critical role in brain disorders. Cyclooxygenase (COX) is one of the principal drug targets for the reduction of neuroinflammation; however, studies have yielded mixed results for COX-inhibitors in the treatment of diverse acute and chronic models of epilepsy.
The article covers the effects of COX-inhibitors in epilepsy disorders. A considerable emphasis has been placed on the antiepileptic and 'disease-modifying' properties of COX-1 and COX-2 inhibitors in various preclinical epilepsy models.
The effect of COX-inhibitors on epilepsy is inconclusive. Studies have indicated beneficial effects in preclinical models; however, proconvulsant or no effects have also been observed. These molecules may have a bidirectional role with early neuroprotective and delayed neurotoxic effects. Further systematic preclinical studies to establish the use of COX-inhibitors in epilepsy are necessary.
神经炎症在脑部疾病中起着关键作用。环氧化酶（COX）是减少神经炎症的主要药物靶点之一；然而，在治疗各种急性和慢性癫痫模型中，COX 抑制剂的研究结果喜忧参半。
本文涵盖了 COX 抑制剂在癫痫疾病中的作用。本文特别强调了 COX-1 和 COX-2 抑制剂在各种临床前癫痫模型中的抗癫痫和“疾病修饰”特性。
COX 抑制剂对癫痫的影响尚无定论。研究表明这些药物在临床前模型中具有有益的作用；然而，也观察到了致惊厥或无作用。这些分子可能具有双向作用，早期具有神经保护作用，晚期具有神经毒性作用。有必要进一步进行系统的临床前研究，以确定 COX 抑制剂在癫痫中的应用。
