Tillet Y
Laboratoire de Neuroendocrinologie, INRA, Centre de Recherches de Tours, Monnaie, France.
Anat Embryol (Berl). 1988;178(5):429-40. doi: 10.1007/BF00306049.
Using immunohistochemistry with specific antiserotonin anti-sera, the ontogeny of serotonergic neurons was studied in the foetal sheep brain. Serotonergic-immunoreactive perikarya first appeared rostrally on day 25 of pregnancy, in the medio-ventral part of the mesencephalic flexure, and caudally, on day 28, in the medio-ventral part of the cervical flexure. The development of this system is very rapid, because on day 40 of gestation, all serotonergic nuclei present in the adult were visible. Compared with other species such as rodents or primates, serotonin appears early in the sheep nervous system, and the development of the serotonergic system is even more rapid. Serotonergic immunoreactivity was seen in some cell bodies in the growing adenohypophysis between days 40 and 50. This phenomenon has not been observed in other species. Because serotonin appears very early and is present in growing areas of the nervous system, it could play a trophic role in the development and maturation of the sheep central nervous system, as has been described previously in other species.
利用针对血清素的特异性抗血清进行免疫组织化学，研究了胎羊脑中血清素能神经元的个体发生。血清素免疫反应阳性的核周体最早在妊娠第25天出现在脑前部，位于中脑弯曲的中腹侧部分，而在第28天出现在脑后部，位于颈弯曲的中腹侧部分。该系统的发育非常迅速，因为在妊娠第40天时，成年羊体内所有的血清素能核都已可见。与啮齿动物或灵长类等其他物种相比，血清素在绵羊神经系统中出现得较早，且血清素能系统的发育更为迅速。在第40天至50天之间，在生长中的腺垂体的一些细胞体中可见血清素免疫反应性。这种现象在其他物种中尚未观察到。由于血清素出现得非常早且存在于神经系统的生长区域，它可能在绵羊中枢神经系统的发育和成熟中发挥营养作用，正如之前在其他物种中所描述的那样。
