脑源性神经营养因子的血浆水平与缺血性中风急性期的预后相关。
Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke.
作者信息
Mourão Aline Mansueto, Vicente Laélia Cristina Caseiro, Abreu Mery Natali Silva, Vale Sant'Anna Romeu, Vieira Erica Leandro Marciano, de Souza Leonardo Cruz, de Miranda Aline Silva, Rachid Milene Alvarenga, Teixeira Antônio Lucio
机构信息
Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Sector of the Stroke Unit of the Risoleta Tolentino Neves Hospital, Belo Horizonte, Minas Gerais, Brazil; Department of Speech Therapy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Department of Speech Therapy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
出版信息
J Stroke Cerebrovasc Dis. 2019 Mar;28(3):735-740. doi: 10.1016/j.jstrokecerebrovasdis.2018.11.013. Epub 2018 Dec 3.
CONTEXT
Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neuronal survival, differentiation, and maturation.
PURPOSE
To evaluate the levels of BDNF in the acute phase of stroke and their potential association with neurological impairment.
METHODS
Patients in the acute phase of ischemic stroke were evaluated with the following clinical tools: National Institutes of Health Stroke Scale, modified Rankin scale, Gugging Swallowing Screen and Alberta Stroke Program Early CT Score. Blood samples were collected at 3 different moments of hospital stay. BDNF was measured through enzyme-linked immunosorbent assay.
RESULTS
Patients who were discharged after 10 days had worse clinical outcomes and higher levels of BDNF since admission. There was correlation between BDNF levels and clinical parameters.
CONCLUSION
BDNF levels were associated with clinical prognosis in the acute phase of ischemic stroke.
背景
脑源性神经营养因子（BDNF）是一种参与神经元存活、分化和成熟的神经营养因子。
目的
评估中风急性期BDNF水平及其与神经功能缺损的潜在关联。
方法
采用以下临床工具对缺血性中风急性期患者进行评估：美国国立卫生研究院卒中量表、改良Rankin量表、古根吞咽筛查量表和阿尔伯塔卒中项目早期CT评分。在住院期间的3个不同时间点采集血样。通过酶联免疫吸附测定法测量BDNF。
结果
10天后出院的患者临床结局较差，自入院以来BDNF水平较高。BDNF水平与临床参数之间存在相关性。
结论
BDNF水平与缺血性中风急性期的临床预后相关。
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