天然α-干扰素（HLBI）治疗成人T细胞白血病的临床研究
[Clinical study on the effect of natural alpha-interferon (HLBI) in the treatment of adult T-cell leukemia].
作者信息
Ichimaru M, Kamihira S, Moriuchi Y, Kuraishi Y, Usui N, Toki H, Okabe K, Niho Y, Shibuya T, Umei T
机构信息
Dept. of Hematology, Nagasaki University, School of Medicine.
出版信息
Gan To Kagaku Ryoho. 1988 Oct;15(10):2975-81.
The phase II trial of natural interferon-alpha (HLBI) in treatment of adult T-cell leukemia was carried out as a cooperative study. Of the 24 cases which could be evaluated, 3 cases in crisis type and 5 cases in chronic type with lymphadenopathy and/or skin infiltration achieved PR, giving a response rate of 33.3%. The anti-tumor effect of HLBI for skin lesion could be assessed in 16 cases with skin infiltration, giving a response rate of 50.0% (5 CR and 3 PR) and demonstrating a high efficacy. Of the 31 eligible patients, side effects were recognised in 27 (87.1%). Major subjective and objective symptoms were fever (38.7%), fatigue (25.8%), anorexia (12.9%) and nausea (12.9%), and leukopenia (22.6%), granulocytopenia (38.7%), thrombocytopenia (38.7), elevation of GPT (12.9%) and GOT (12.9%) were observed.
天然干扰素α（HLBI）治疗成人T细胞白血病的II期试验作为一项合作研究开展。在可评估的24例患者中，3例危象型和5例伴有淋巴结病和/或皮肤浸润的慢性型患者达到部分缓解（PR），缓解率为33.3%。HLBI对皮肤病变的抗肿瘤作用可在16例有皮肤浸润的患者中进行评估，缓解率为50.0%（5例完全缓解和3例部分缓解），显示出高效性。在31例符合条件的患者中，27例（87.1%）出现了副作用。主要的主观和客观症状为发热（38.7%）、疲劳（25.8%）、厌食（12.9%）和恶心（12.9%），并观察到白细胞减少（22.6%）、粒细胞减少（38.7%）、血小板减少（38.7%）、谷丙转氨酶（GPT）升高（12.9%）和谷草转氨酶（GOT）升高（12.9%）。
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