Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Zurich 8092, Switzerland. Department of Radiation Oncology, University Hospital Zurich, Zurich 8091, Switzerland.
Phys Med Biol. 2018 Dec 19;64(1):015001. doi: 10.1088/1361-6560/aaf361.
In precision radiotherapy, the intrafractional motion can cause a considerable uncertainty of the location of the tumor to be treated. An established approach is the expansion of the target volume to account for the motion. An alternative approach is couch-tracking, in which the patient is continually moved to compensate the intrafractional motion. However, couch-tracking itself might induce uncertainty of the patient's body position, because the body is non-rigid. One hundred healthy volunteers were positioned supine on a robotic couch. Optical markers were placed on the torso of the volunteers as well as on the couch, and their positions were tracked with an optical surface measurement system. Using these markers, the uncertainty of the body position relative to the couch position was estimated while the couch was static or moving. Over the included 83 healthy volunteers, the median of the uncertainty increased by 0.8 mm (SI), 0.4 mm (LR) and 0.4 mm (AP) when the couch moved. Couch motion was found to increase the uncertainty of the body position relative to the couch. However, this uncertainty is one order of magnitude smaller than the intrafractional tumor motion amplitudes to be compensated. Therefore, even with body motion present, the couch-tracking approach is a viable option. The study was registered at ClinicalTrials.gov (NCT02820532) and the Swiss national clinical trials portal (SNCTP000001878).
在精确放疗中,分次内运动可导致待治疗肿瘤位置的显著不确定性。一种已确立的方法是扩大目标体积以适应运动。另一种方法是床跟踪,其中患者持续移动以补偿分次内运动。然而,床跟踪本身可能会导致患者身体位置的不确定性,因为身体是非刚性的。一百名健康志愿者仰卧在机器人床上。光学标记物被放置在志愿者的躯干上和床上,并使用光学表面测量系统跟踪它们的位置。使用这些标记物,当床静止或移动时,估计了相对于床位置的身体位置的不确定性。在包括的 83 名健康志愿者中,当床移动时,不确定性的中位数增加了 0.8 mm(SI)、0.4 mm(LR)和 0.4 mm(AP)。发现床的运动会增加相对于床的身体位置的不确定性。然而,这种不确定性是要补偿的分次内肿瘤运动幅度的一个数量级小。因此,即使存在身体运动,床跟踪方法也是可行的选择。该研究在 ClinicalTrials.gov(NCT02820532)和瑞士国家临床试验门户(SNCTP000001878)上进行了注册。