临床肿瘤学中的下一代测序：应用、挑战与前景：一篇综述文章
Next Generation Sequencing in Clinical Oncology: Applications, Challenges and Promises: A Review Article.
作者信息
Shabani Azim Faezeh, Houri Hamidreza, Ghalavand Zohreh, Nikmanesh Bahram
机构信息
Student Scientific Research Center, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
Dept. of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Public Health. 2018 Oct;47(10):1453-1457.
Abstract
BACKGROUND
The aim of this mini-review is to highlight the potential applications of next-generation sequencing technology to the field of clinical oncology with respect to genetic diagnosis, cancer classification, predictive biomarkers and personalized medicine.
METHODS
Scientific databases were searched to collect relative data.
RESULTS
Effective systematic analysis of whole-genome sequence and whole-exome sequence of tumors, targeted genome profiling, transcriptome sequencing and tumor-normal comparisons can be performed using NGS in order to diagnosis of several types of cancer.
CONCLUSION
NGS technology can be powerful enough to discover new and infrequent gene alterations, identify hereditary cancer mutation carriers and provide a reliable molecular portrait of wide range of cancers in a quick and cost-effective manner.
摘要
背景
本小型综述的目的是强调下一代测序技术在临床肿瘤学领域在基因诊断、癌症分类、预测性生物标志物和个性化医疗方面的潜在应用。
方法
检索科学数据库以收集相关数据。
结果
使用下一代测序技术可以对肿瘤的全基因组序列和全外显子组序列进行有效的系统分析、靶向基因组分析、转录组测序以及肿瘤与正常组织的比较，以便诊断多种类型的癌症。
结论
下一代测序技术强大到足以发现新的和罕见的基因改变，识别遗传性癌症突变携带者，并以快速且经济高效的方式提供多种癌症的可靠分子图谱。
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