间充质基质细胞作为神经系统疾病的一种潜在治疗手段。
Mesenchymal stromal cells as a potential therapeutic for neurological disorders.
作者信息
Mukai Takeo, Tojo Arinobu, Nagamura-Inoue Tokiko
机构信息
Division of Molecular of Therapy, Center for Advanced Medical Research, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Department of Cell Processing and Transfusion, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
出版信息
Regen Ther. 2018 Aug 24;9:32-37. doi: 10.1016/j.reth.2018.08.001. eCollection 2018 Dec.
Several studies have reported that mesenchymal stromal/stem cells (MSCs) restore neurological damage through their secretion of paracrine factors or their differentiation to neuronal cells. Based on these studies, many clinical trials have been conducted using MSCs for neurological disorders, and their safety and efficacy have been reported. In this review, we provide a brief introduction to MSCs, especially umbilical cord derived-MSCs (UC-MSCs), in terms of characteristics, isolation, and cryopreservation, and discuss the recent progress in regenerative therapies using MSCs for various neurological disorders.
多项研究报告称，间充质基质/干细胞（MSCs）通过分泌旁分泌因子或分化为神经元细胞来修复神经损伤。基于这些研究，已经开展了许多使用MSCs治疗神经疾病的临床试验，并报告了其安全性和有效性。在本综述中，我们简要介绍了MSCs，尤其是脐带间充质干细胞（UC-MSCs）的特征、分离和冷冻保存，并讨论了使用MSCs治疗各种神经疾病的再生疗法的最新进展。
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