Alvestrand A, Zimmerman L, Bergström J
Department of Renal Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Blood Purif. 1988;6(5):276-84. doi: 10.1159/000169555.
Increases in renal blood flow and glomerular filtration rate occur following the ingestion of a protein-rich meal. It has been postulated that this renal response is stimulated by some hormonal factor. Glucagon has been proposed as a probable mediating hormone, but results of recent studies argue against a direct mediating effect of glucagon. It is postulated that glomerular hyperfiltration induced by various stimuli (protein ingestion, amino acid infusion, glucagon infusion, diabetes mellitus) is associated with increased secretion by the liver of a factor that increases glomerular filtration rate. Preliminary data suggest that serotonin might play a role in mediating the postprandial increases in renal hemodynamics following protein ingestion.
摄入富含蛋白质的食物后，肾血流量和肾小球滤过率会增加。据推测，这种肾脏反应是由某种激素因子刺激引起的。有人提出胰高血糖素可能是一种介导激素，但最近的研究结果反对胰高血糖素的直接介导作用。据推测，由各种刺激（蛋白质摄入、氨基酸输注、胰高血糖素输注、糖尿病）诱导的肾小球高滤过与肝脏分泌增加一种可提高肾小球滤过率的因子有关。初步数据表明，血清素可能在介导蛋白质摄入后餐后肾脏血流动力学的增加中起作用。
