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癌细胞重编程伤口愈合开关以促进转移。

Carcinoma Cells Reprogram a Wound-healing Switch to Promote Metastasis.

作者信息

Sundaram Gopinath M, Sampath Prabha

机构信息

Institute of Medical Biology, Agency for Science Technology & Research (ASTAR), Singapore 138648.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

出版信息

Mol Cell Oncol. 2018 Sep 20;5(6):e1432255. doi: 10.1080/23723556.2018.1432255. eCollection 2018.

DOI:10.1080/23723556.2018.1432255
PMID:30525085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6276847/
Abstract

Wound healing is a dynamic event where barrier disruption is transient and miR-198/FSTL1 molecular switch orchestrate wound re-epithelialization. However, epithelial carcinomas maintain a prolonged wound-healing phase to promote malignant transformation. Delineating the molecular mechanism we demonstrate, how epidermal growth factor (EGF) hijacks the wound-healing switch to promote metastasis of carcinoma.

摘要

伤口愈合是一个动态过程，在此过程中屏障破坏是短暂的，且miR-198/FSTL1分子开关协调伤口的重新上皮化。然而，上皮癌维持一个延长的伤口愈合阶段以促进恶性转化。我们阐述了分子机制，即表皮生长因子（EGF）如何劫持伤口愈合开关来促进癌转移。

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本文引用的文献

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EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis.表皮生长因子劫持了miR-198/FSTL1伤口愈合开关，并引导一条双管齐下的转移途径。
J Exp Med. 2017 Oct 2;214(10):2889-2900. doi: 10.1084/jem.20170354. Epub 2017 Aug 21.
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Anti-EGFR Therapy: Strategies in Head and Neck Squamous Cell Carcinoma.抗表皮生长因子受体治疗：头颈部鳞状细胞癌的治疗策略
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'See-saw' expression of microRNA-198 and FSTL1 from a single transcript in wound healing.miRNA-198 和 FSTL1 在创伤愈合中从单个转录本中呈现“跷跷板”表达。
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Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation.Wnt-7a表达的恢复通过卷曲蛋白-9介导的生长抑制和促进细胞分化来逆转非小细胞肺癌细胞的转化。
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Expression of matrix metalloproteinase-9 in head and neck squamous cell carcinoma: a potential marker for prognosis.基质金属蛋白酶-9在头颈部鳞状细胞癌中的表达：一种潜在的预后标志物。
Clin Cancer Res. 2004 May 1;10(9):3110-6. doi: 10.1158/1078-0432.ccr-03-0530.